Acute physiological effects on macromolecule digestion following oral ingestion of the enzyme blend Elevase® in individuals that had undergone an ileostomy, but were otherwise healthy-a randomized, double blinded, placebo-controlled exploratory study.

Digestive enzymes can selectively degrade proteins, carbohydrates and lipids; and their supplementation alongside food may accelerate the breakdown of complex food matrices, facilitate greater nutrient absorption, decrease food sensitivities and aid in the management of certain disease states. Several intrinsic and extrinsic factors govern food digestion and for every individual this phenomenon is unique. This study was conducted as a randomized, crossover, placebo-controlled design where each participant served as their own control. This post-hoc analysis investigated the impact of a dietary enzyme supplementation blend known as Elevase® on dietary macromolecule digestion in samples from otherwise healthy participants that had previously undergone a small bowel resection, resulting in an ileostomy (NCT04489810). This is the first time this study-paradigm has been used for the assessment of

Informations de copyright

Copyright © 2024 Mazhar, Simon, Colom, Khokhlova, Buckley, Phipps, Deaton and Rea.

Déclaration de conflit d'intérêts

SM, AS, JC, EK, CP, JD, and KR are employees of ADM/Deerland Probiotics and Enzymes, and contributed to the study design, execution, data management, data analysis, and preparation of this manuscript. Elevase® is a trademark of ADM/Deerland Probiotic and Enzymes. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.