Retro-age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements.
DNA methylation
aging
biomarker
endogenous retrovirus
epigenetic clock
epigenetics
retroelement
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
02 Aug 2024
02 Aug 2024
Historique:
revised:
11
07
2024
received:
15
02
2024
accepted:
16
07
2024
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
2
8
2024
Statut:
aheadofprint
Résumé
Reactivation of retroelements in the human genome has been linked to aging. However, whether the epigenetic state of specific retroelements can predict chronological age remains unknown. We provide evidence that locus-specific retroelement DNA methylation can be used to create retroelement-based epigenetic clocks that accurately measure chronological age in the immune system, across human tissues, and pan-mammalian species. We also developed a highly accurate retroelement epigenetic clock compatible with EPICv.2.0 data that was constructed from CpGs that did not overlap with existing first- and second-generation epigenetic clocks, suggesting a unique signal for epigenetic clocks not previously captured. We found retroelement-based epigenetic clocks were reversed during transient epigenetic reprogramming, accelerated in people living with HIV-1, and responsive to antiretroviral therapy. Our findings highlight the utility of retroelement-based biomarkers of aging and support a renewed emphasis on the role of retroelements in geroscience.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14288Subventions
Organisme : NIH HHS
ID : R01AG082056
Pays : United States
Organisme : NIH HHS
ID : R01HL160392
Pays : United States
Organisme : NIH HHS
ID : R01MH134391
Pays : United States
Organisme : NIH HHS
ID : UM1AI164559
Pays : United States
Informations de copyright
© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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