Impact of Experimental Tuberculosis on Fertility of Female BALB/c Mice.

M. tuberculosis inbred mice microbiota pregnancy

Journal

Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557

Informations de publication

Date de publication:
02 Aug 2024
Historique:
received: 23 10 2023
medline: 2 8 2024
pubmed: 2 8 2024
entrez: 2 8 2024
Statut: aheadofprint

Résumé

The study revealed no effects of pregnancy and childbirth on the course of tuberculosis in female BALB/c mice after aerosol infection with Mycobacterium tuberculosis. However, we demonstrated a negative effect of tuberculosis infection on the fertility of infected females, which manifested in a longer period from mating to pregnancy and in a smaller litter size. Impaired reproductive function in response to the effect of the systemic infectious process was accompanied by the development of immunosuppression confirmed by an immunological test (delayed-type hypersensitivity to tuberculin) and the formation of genital tract dysbiosis during pregnancy and postpartum period.

Identifiants

DOI: 10.1007/s10517-024-06168-y PMID: 39093472
pubmed: 39093472
doi: 10.1007/s10517-024-06168-y
pii: 10.1007/s10517-024-06168-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

S I Kayukova (SI)

Central Research Institute of Tuberculosis, Moscow, Russia. kajukovalnp@gmail.com.

N L Karpina (NL)

Central Research Institute of Tuberculosis, Moscow, Russia.

V A Ulyumdzhieva (VA)

Central Research Institute of Tuberculosis, Moscow, Russia.

L A Semenova (LA)

Central Research Institute of Tuberculosis, Moscow, Russia.

A E Donnikov (AE)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.

I V Bocharova (IV)

Central Research Institute of Tuberculosis, Moscow, Russia.

B V Nikonenko (BV)

Central Research Institute of Tuberculosis, Moscow, Russia.

Classifications MeSH