Early-life risperidone alters locomotor responses to apomorphine and quinpirole in adulthood.
D2 receptor
antipsychotic
development
dopamine
sex difference
supersensitivity
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
received:
12
04
2024
revised:
12
07
2024
accepted:
29
07
2024
medline:
3
8
2024
pubmed:
3
8
2024
entrez:
2
8
2024
Statut:
aheadofprint
Résumé
An escalating trend of antipsychotic drug use in children with ADHD, disruptive behavior disorder, or mood disorders has raised concerns about the impact of these drugs on brain development. Since antipsychotics chiefly target dopamine receptors, it is important to assay the function of these receptors after early-life antipsychotic administration. Using rats as a model, we examined the effects of early-life risperidone, the most prescribed antipsychotic drug in children, on locomotor responses to the dopamine D
Identifiants
pubmed: 39094954
pii: S0166-4328(24)00327-9
doi: 10.1016/j.bbr.2024.115171
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115171Informations de copyright
Copyright © 2024. Published by Elsevier B.V.