Dissociating the metabolic and tumor-suppressive activity of p53.
cancer
inflammation
insulin resistance
obesity
oncogenesis
p53
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
received:
30
06
2024
revised:
24
07
2024
accepted:
24
07
2024
medline:
3
8
2024
pubmed:
3
8
2024
entrez:
2
8
2024
Statut:
aheadofprint
Résumé
The tumor suppressor p53 regulates metabolic homeostasis. Recently, Tsaousidou et al. reported that selective activation of p53 via downregulation of Tudor interacting repair regulator (TIRR) confers protection against cancer despite obesity and insulin resistance, providing new insights into the role of p53 at the intersection of oncogenesis and systemic metabolism.
Identifiants
pubmed: 39095229
pii: S1043-2760(24)00199-1
doi: 10.1016/j.tem.2024.07.018
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors have no conflicts of interests to declare.