Astrocyte-derived apolipoprotein D is required for neuronal survival in Parkinson's disease.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
02 Aug 2024
02 Aug 2024
Historique:
received:
05
02
2024
accepted:
12
07
2024
medline:
3
8
2024
pubmed:
3
8
2024
entrez:
2
8
2024
Statut:
epublish
Résumé
Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an essential role in several neurodegenerative diseases. It was reported that increased immunostaining for ApoD of glial cells surrounding dopaminergic (DAergic) neurons was observed in the brains of Parkinson's disease (PD) patients. Although preliminary findings supported the role of ApoD in neuroprotection, its derivation and effects on the degeneration of nigral DAergic neurons are largely unknown. In the present study, we observed that ApoD levels released from astrocytes were increased in PD models both in vivo and in vitro. When co-cultured with astrocytes, due to the increased release of astrocytic ApoD, the survival rate of primary cultured ventral midbrain (VM) neurons was significantly increased with 1-methyl-4-phenylpyridillium ion (MPP
Identifiants
pubmed: 39095480
doi: 10.1038/s41531-024-00753-8
pii: 10.1038/s41531-024-00753-8
doi:
Types de publication
Journal Article
Langues
eng
Pagination
143Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32171131
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32371013
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82071429
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32371181
Organisme : Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
ID : 2021ZDSYS11
Organisme : Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
ID : ZR2019ZD31
Organisme : Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
ID : ZR2020QH125
Organisme : Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
ID : ZR2022MC098
Informations de copyright
© 2024. The Author(s).
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