Allogeneic stem cell transplantation in de novo core-binding factor acute myeloid leukemia in first complete remission: data from the EBMT.


Journal

Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459

Informations de publication

Date de publication:
02 Aug 2024
Historique:
received: 20 11 2023
accepted: 11 07 2024
medline: 3 8 2024
pubmed: 3 8 2024
entrez: 2 8 2024
Statut: aheadofprint

Résumé

Core-binding factor acute myeloid leukemia (CBF-AML) represents 12-15% of all AML cases. Although CBF positivity infers a survival advantage, overall survival (OS) remains dismal. Treatment is with cytarabine/anthracycline-based chemotherapy induction followed by high-dose cytarabine (HiDAC) consolidation. Allogeneic hematopoietic stem cell transplantation (allo-SCT) is reserved for relapse or for patients having not achieved MRD-negativity at high risk for relapse. The role of SCT in first complete remission (CR1) remains controversial and is considered in high risk conditions. In this retrospective, multi-national, European Society for Blood and Marrow Transplantation (EBMT)-based study, we identified 1901 patients with de novo CBF-AML who received an allo-SCT or autologous transplantation (ASCT) in CR1. 65.5% harbored t(8;21) and 34.4% inv(16). In this group, the majority (77%) were treated with allo-SCT in CR1. In multivariate analysis, treatment with allo-SCT was an independent and significant, negative predictor of NRM and OS (HR 4.26, p < 0.0001 and HR 1.67, p = 0.003) and among patients treated with allo-SCT, those treated with MSD had the best outcomes, comparable to those treated with ASCT. There was no interaction between the type of transplant and MRD status at time of SCT. In both, MRD-negative and MRD-positive groups, NRM was worse in the allo-SCT group (MRD-: 12.9% vs 5.2%, p = 0.007; MRD+: 10.6% vs 0%, p = 0.004). We therefore demonstrated that consolidation in CR1 with allo-SCT results in worse outcomes than ASCT. Whether consolidation with ASCT yields better outcomes than chemotherapy alone or chemotherapy in combination with Gemtuzumab Ozogamicin is yet to be investigated.

Identifiants

pubmed: 39095548
doi: 10.1038/s41409-024-02373-5
pii: 10.1038/s41409-024-02373-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Rama Al Hamed (R)

EBMT Paris study office / CEREST-TC, Paris, France, Department of Hematology, Saint Antoine Hospital, Paris, France, INSERM UMR 938, Sorbonne University, Paris, France.
Department of Internal Medicine, Jacobi Medical Center/Einstein College of Medicine, Bronx, NY, USA.

Myriam Labopin (M)

EBMT Paris study office / CEREST-TC, Paris, France, Department of Hematology, Saint Antoine Hospital, Paris, France, INSERM UMR 938, Sorbonne University, Paris, France.

Depei Wu (D)

First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, China.

Tobias Gedde-Dahl (T)

Oslo University Hospital, Rikshospitalet, Clinic for Cancer Medicine, Hematology Dept. Section for Stem Cell Transplantation, Oslo, Norway.

Mahmoud Aljurf (M)

King Faisal Specialist Hospital & Research Centre Oncology (Section of Adult Haematolgy/BMT), Riyadh, Saudi Arabia.

Edouard Forcade (E)

CHU Bordeaux, Hôpital Haut-l 'Evêque, Pessac, France.

Urpu Salmenniemi (U)

HUCH Comprehensive Cancer Center, Stem Cell Transplantation Unit, Helsinki, Finland.

Jakob Passweg (J)

University Hospital, Hematology, Basel, Switzerland.

Johan Maertens (J)

University Hospital Gasthuisberg, Dept. of Hematology, Leuven, Belgium.

Thomas Pabst (T)

Department of Medical Oncology, University Hospital; Inselspital, Bern, Switzerland.

Jurjen Versluis (J)

Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Maija Itäla-Remes (M)

Turku University Hospital, Stem Cell Transplant Unit, Turku, Finland.

Xiao-Jun Huang (XJ)

Peking University People´s Hospital, Institute of Haematology, Beijing, China.

Gwendolyn Van Gorkom (G)

Department of Internal Medicine, Division of Hematology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

Thomas Schroeder (T)

University Hospital, Dept. of Bone Marrow Transplantation, Essen, Germany.

Jaime Sanz (J)

University Hospital La Fe, Hematology Department, Valencia, Spain.

Didier Blaise (D)

Programme de Transplantation and Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Marseille, France.

Péter Reményi (P)

Dél-pesti Centrumkórház -Országos Hematológiai és Infektológiai Intézet, Dept. Haematology and Stem Cell Transplant, Budapest, Hungary.

Urs Schanz (U)

University Hospital, Clinic of Hematology, Zurich, Switzerland.

Jordi Esteve (J)

Department of Hematology, Hospital Clínic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.

Norbert-Claude Gorin (NC)

EBMT Paris study office / CEREST-TC, Paris, France, Department of Hematology, Saint Antoine Hospital, Paris, France, INSERM UMR 938, Sorbonne University, Paris, France.

Fabio Ciceri (F)

IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milano, Italy.

Mohamad Mohty (M)

EBMT Paris study office / CEREST-TC, Paris, France, Department of Hematology, Saint Antoine Hospital, Paris, France, INSERM UMR 938, Sorbonne University, Paris, France. mohamad.mohty@inserm.fr.

Classifications MeSH