A preliminary investigation into the impact of soft tissue augmentation-based periodontal phenotype modification therapy for patients exhibiting class III decompensation.
Humans
Gingival Recession
/ surgery
Malocclusion, Angle Class III
/ therapy
Female
Gingiva
/ pathology
Male
Tooth Movement Techniques
/ methods
Phenotype
Connective Tissue
/ transplantation
Adult
Young Adult
Follow-Up Studies
Mandible
/ surgery
Tooth Cervix
/ pathology
Biopsy
Gingivoplasty
/ methods
Minimally Invasive Surgical Procedures
/ methods
Gingival recession
Periodontal phenotype modification
Skeletal angle class III malocclusion
Soft tissue augmentation
Soft tissue grafting
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
02 Aug 2024
02 Aug 2024
Historique:
received:
15
03
2024
accepted:
17
07
2024
medline:
3
8
2024
pubmed:
3
8
2024
entrez:
2
8
2024
Statut:
epublish
Résumé
Patients with skeletal angle Class III malocclusion usually have inadequate hard and soft tissue volume at the mandibular anterior teeth. The labial proclination at the teeth may lead to gingival recession. The purpose of this study was to explore whether periodontal phenotype modification therapy with soft tissue augmentation (PhMT-s) can prevent gingival recession in these patients. Four patients with skeletal Class III malocclusion and a thin periodontal phenotype underwent surgical-orthodontic treatment. Prior to tooth movement, they underwent a minimally invasive vestibular incision with subperiosteal tunnel access combined with autogenous connective tissue grafts for periodontal phenotype modification with soft tissue augmentation (PhMT-s). The labial gingival thickness of the anterior mandibular teeth was measured at three distinct levels: at the cementoenamel junction (GT0), 3 mm apical to the CEJ (GT3), and 6 mm apical to the CEJ (GT6). These measurements were taken at baseline, three months following PhMT-s, and after tooth decompensation. Additionally, a biopsy sample was obtained from the PhMT-s site of one patient. All sections were subsequently stained using hematoxylin and eosin, Masson trichrome, Sirius Red, and immunohistochemistry. The thickness of the labial gingiva was increased about 0.42 to 2.00 mm after PhMT-s. At the end of pre-orthognathic surgical orthodontic treatment, the thickness of the labial gingiva was increased about - 0.14 to 1.32 mm compared to the baseline and no gingival recession occurred after the pre-orthognathic surgical orthodontic treatment. The histologic results demonstrated that the grafts obtained from the PhMT-s site exhibited increased deposition of collagen fibers. Moreover, the proportion of type III collagen increased and the grafts displayed significantly reduced positive expression of CD31 and OCN. PhMT-s increased the thickness of the soft tissue, stabilizing the gingival margin for teeth exhibiting a thin periodontal phenotype and undergoing labial movement. This is attributed to the increased deposition of collagen fibers.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with skeletal angle Class III malocclusion usually have inadequate hard and soft tissue volume at the mandibular anterior teeth. The labial proclination at the teeth may lead to gingival recession. The purpose of this study was to explore whether periodontal phenotype modification therapy with soft tissue augmentation (PhMT-s) can prevent gingival recession in these patients.
METHODS
METHODS
Four patients with skeletal Class III malocclusion and a thin periodontal phenotype underwent surgical-orthodontic treatment. Prior to tooth movement, they underwent a minimally invasive vestibular incision with subperiosteal tunnel access combined with autogenous connective tissue grafts for periodontal phenotype modification with soft tissue augmentation (PhMT-s). The labial gingival thickness of the anterior mandibular teeth was measured at three distinct levels: at the cementoenamel junction (GT0), 3 mm apical to the CEJ (GT3), and 6 mm apical to the CEJ (GT6). These measurements were taken at baseline, three months following PhMT-s, and after tooth decompensation. Additionally, a biopsy sample was obtained from the PhMT-s site of one patient. All sections were subsequently stained using hematoxylin and eosin, Masson trichrome, Sirius Red, and immunohistochemistry.
RESULTS
RESULTS
The thickness of the labial gingiva was increased about 0.42 to 2.00 mm after PhMT-s. At the end of pre-orthognathic surgical orthodontic treatment, the thickness of the labial gingiva was increased about - 0.14 to 1.32 mm compared to the baseline and no gingival recession occurred after the pre-orthognathic surgical orthodontic treatment. The histologic results demonstrated that the grafts obtained from the PhMT-s site exhibited increased deposition of collagen fibers. Moreover, the proportion of type III collagen increased and the grafts displayed significantly reduced positive expression of CD31 and OCN.
CONCLUSIONS
CONCLUSIONS
PhMT-s increased the thickness of the soft tissue, stabilizing the gingival margin for teeth exhibiting a thin periodontal phenotype and undergoing labial movement. This is attributed to the increased deposition of collagen fibers.
Identifiants
pubmed: 39095718
doi: 10.1186/s12903-024-04630-x
pii: 10.1186/s12903-024-04630-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
880Subventions
Organisme : National Natural Science Foundation of China
ID : NO.82301067
Organisme : National Natural Science Foundation of China
ID : NO.82301067
Organisme : National Natural Science Foundation of China
ID : NO.82301067
Organisme : National Natural Science Foundation of China
ID : NO.82301067
Organisme : National Natural Science Foundation of China
ID : NO.82301067
Organisme : Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong university School of Medicine
ID : JYJC202211
Organisme : Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong university School of Medicine
ID : JYJC202211
Organisme : Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong university School of Medicine
ID : JYJC202211
Organisme : Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong university School of Medicine
ID : JYJC202211
Organisme : Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong university School of Medicine
ID : JYJC202211
Organisme : Teachers Practice Plan of Shanghai University
ID : 2022cxy-nj
Organisme : Teachers Practice Plan of Shanghai University
ID : 2022cxy-nj
Organisme : Teachers Practice Plan of Shanghai University
ID : 2022cxy-nj
Organisme : Teachers Practice Plan of Shanghai University
ID : 2022cxy-nj
Organisme : Teachers Practice Plan of Shanghai University
ID : 2022cxy-nj
Organisme : Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
ID : 201912
Organisme : Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
ID : 201912
Organisme : Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
ID : 201912
Organisme : Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
ID : 201912
Organisme : Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
ID : 201912
Informations de copyright
© 2024. The Author(s).
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