A High Dynamic Range Ion Detector for Multireflection Time-of-Flight Analyzers.


Journal

Journal of the American Society for Mass Spectrometry
ISSN: 1879-1123
Titre abrégé: J Am Soc Mass Spectrom
Pays: United States
ID NLM: 9010412

Informations de publication

Date de publication:
03 Aug 2024
Historique:
medline: 4 8 2024
pubmed: 4 8 2024
entrez: 3 8 2024
Statut: aheadofprint

Résumé

Reflectron-based time-of-flight analyzers rely on subnanosecond detector time response to achieve acceptable resolving power for low-mid-mass, multiple-ion peaks. With the adoption of multireflection analyzers, order of magnitude longer folded ion paths relax restrictions on detector response time, allowing implementation of new technologies that greatly improve dynamic range, detector lifetime, and ion detection efficiency. A detection system is presented, integrated into a multireflection analyzer, that combines 10 keV postacceleration and focal plane correction with a unique BxE focusing, optically coupled detector, preamplification, and dual-channel digitization. Calibration and peak-handling methods are also described. The instrument demonstrated >1 × 10

Identifiants

pubmed: 39096288
doi: 10.1021/jasms.4c00230
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Hamish Stewart (H)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Johannes Petzoldt (J)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Toby Shanley (T)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Dmitry Grinfeld (D)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Eduard Denisov (E)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Bernd Hagedorn (B)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Ankit Dwivedi (A)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Daniel Mourad (D)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Robert Ostermann (R)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Maximilian Ochmann (M)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Philipp Cochems (P)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Alexander Wagner (A)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Wilko Balschun (W)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Alexander Makarov (A)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Semyon Shofman (S)

El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.

Ben-David Moti (BD)

El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.

Amit Weingarten (A)

El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.

Sasha Kadyshevitch (S)

El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.

Christian Hock (C)

Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.

Classifications MeSH