Exposome: Epigenetics and autoimmune diseases.
ANCA-associated vasculitis (AAV)
DNA methylation
Epigenetics
Exposome
Idiopathic inflammatory myopathies (IIM)
Non-coding RNAs
Rheumatoid arthritis (RA)
Systemic lupus erythematosus (SLE)
miRNA
Journal
Autoimmunity reviews
ISSN: 1873-0183
Titre abrégé: Autoimmun Rev
Pays: Netherlands
ID NLM: 101128967
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
received:
14
07
2024
revised:
27
07
2024
accepted:
27
07
2024
medline:
4
8
2024
pubmed:
4
8
2024
entrez:
3
8
2024
Statut:
aheadofprint
Résumé
Systemic autoimmune diseases are complex conditions characterized by an immune system dysregulation and an aberrant activation against self-antigens, leading to tissue and organ damage. Even though genetic predisposition plays a role, it cannot fully explain the onset of these diseases, highlighting the significant impact of non-heritable influences such as environment, hormones and infections. The exposome represents all those factors, ranging from chemical pollutants and dietary components to psychological stressors and infectious agents. Epigenetics, which studies changes in gene expression without altering the DNA sequence, is a crucial link between exposome and the development of autoimmune diseases. Key epigenetic mechanisms include DNA methylation, histone modifications, and non-coding RNAs. These epigenetic modifications could provide a potential piece of the puzzle in understanding systemic autoimmune diseases and their connection with the exposome. In this work we have collected the most important and recent evidence in epigenetic changes linked to systemic autoimmune diseases (systemic lupus erythematosus, idiopathic inflammatory myopathies, ANCA-associated vasculitis, and rheumatoid arthritis), emphasizing the roles these changes may play in disease pathogenesis, their potential as diagnostic biomarkers and their prospective in the development of targeted therapies.
Identifiants
pubmed: 39097180
pii: S1568-9972(24)00075-2
doi: 10.1016/j.autrev.2024.103584
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103584Informations de copyright
Copyright © 2024. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. MGD, SG, and YS were responsible for the study's conception and design. MC, AP, MB, and MS reviewed the studies and wrote the first draft. MC drawn the figure. All Authors contributed to analyses of the references. MGD, SG, and YS revised the manuscript critically for intellectual content. All authors gave their final approval of the version of the manuscript to be published.