Exposome: Epigenetics and autoimmune diseases.

ANCA-associated vasculitis (AAV) DNA methylation Epigenetics Exposome Idiopathic inflammatory myopathies (IIM) Non-coding RNAs Rheumatoid arthritis (RA) Systemic lupus erythematosus (SLE) miRNA

Journal

Autoimmunity reviews
ISSN: 1873-0183
Titre abrégé: Autoimmun Rev
Pays: Netherlands
ID NLM: 101128967

Informations de publication

Date de publication:
01 Aug 2024
Historique:
received: 14 07 2024
revised: 27 07 2024
accepted: 27 07 2024
medline: 4 8 2024
pubmed: 4 8 2024
entrez: 3 8 2024
Statut: aheadofprint

Résumé

Systemic autoimmune diseases are complex conditions characterized by an immune system dysregulation and an aberrant activation against self-antigens, leading to tissue and organ damage. Even though genetic predisposition plays a role, it cannot fully explain the onset of these diseases, highlighting the significant impact of non-heritable influences such as environment, hormones and infections. The exposome represents all those factors, ranging from chemical pollutants and dietary components to psychological stressors and infectious agents. Epigenetics, which studies changes in gene expression without altering the DNA sequence, is a crucial link between exposome and the development of autoimmune diseases. Key epigenetic mechanisms include DNA methylation, histone modifications, and non-coding RNAs. These epigenetic modifications could provide a potential piece of the puzzle in understanding systemic autoimmune diseases and their connection with the exposome. In this work we have collected the most important and recent evidence in epigenetic changes linked to systemic autoimmune diseases (systemic lupus erythematosus, idiopathic inflammatory myopathies, ANCA-associated vasculitis, and rheumatoid arthritis), emphasizing the roles these changes may play in disease pathogenesis, their potential as diagnostic biomarkers and their prospective in the development of targeted therapies.

Identifiants

pubmed: 39097180
pii: S1568-9972(24)00075-2
doi: 10.1016/j.autrev.2024.103584
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103584

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. MGD, SG, and YS were responsible for the study's conception and design. MC, AP, MB, and MS reviewed the studies and wrote the first draft. MC drawn the figure. All Authors contributed to analyses of the references. MGD, SG, and YS revised the manuscript critically for intellectual content. All authors gave their final approval of the version of the manuscript to be published.

Auteurs

Maria Giovanna Danieli (MG)

SOS Immunologia delle Malattie Rare e dei Trapianti, AOU delle Marche & Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, via Tronto 10/A, 60126 Torrette di Ancona, Italy; Postgraduate School of Allergy and Clinical Immunology, Università Politecnica delle Marche, via Tronto 10/A, 60126 Ancona, Italy. Electronic address: m.g.danieli@univpm.it.

Marco Casciaro (M)

Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy. Electronic address: marco.casciaro@unime.it.

Alberto Paladini (A)

PostGraduate School of Internal Medicine, Università Politecnica delle Marche, via Tronto 10/A, 60126 Ancona, Italy.

Martina Bartolucci (M)

Postgraduate School of Allergy and Clinical Immunology, Università Politecnica delle Marche, via Tronto 10/A, 60126 Ancona, Italy.

Martina Sordoni (M)

Postgraduate School of Allergy and Clinical Immunology, Università Politecnica delle Marche, via Tronto 10/A, 60126 Ancona, Italy.

Yehuda Shoenfeld (Y)

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52621, Israel; Reichman University, Herzelia 46101, Israel. Electronic address: yehuda.shoenfeld@sheba.health.gov.il.

Sebastiano Gangemi (S)

Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy. Electronic address: sebastiano.gangemi@unime.it.

Classifications MeSH