Predictive signature of murine and human host response to typical and atypical pneumonia.
Animals
Humans
Mice
Streptococcus pneumoniae
/ genetics
Pneumonia, Mycoplasma
/ diagnosis
Mycoplasma pneumoniae
/ genetics
Disease Models, Animal
Female
Pneumonia, Pneumococcal
/ microbiology
Orthomyxoviridae Infections
/ immunology
ROC Curve
Gene Expression Profiling
Pneumonia, Viral
/ diagnosis
Mice, Inbred C57BL
Pneumonia, Bacterial
/ microbiology
Host-Pathogen Interactions
Bacterial Infection
Pneumonia
Respiratory Infection
Sensitivity and Specificity
Viral infection
Journal
BMJ open respiratory research
ISSN: 2052-4439
Titre abrégé: BMJ Open Respir Res
Pays: England
ID NLM: 101638061
Informations de publication
Date de publication:
03 Aug 2024
03 Aug 2024
Historique:
received:
06
08
2023
accepted:
08
07
2024
medline:
4
8
2024
pubmed:
4
8
2024
entrez:
3
8
2024
Statut:
epublish
Résumé
Pneumonia due to typical bacterial, atypical bacterial and viral pathogens can be difficult to clinically differentiate. Host response-based diagnostics are emerging as a complementary diagnostic strategy to pathogen detection. We used murine models of typical bacterial, atypical bacterial and viral pneumonia to develop diagnostic signatures and understand the host's response to these types of infections. Mice were intranasally inoculated with Mice infected with This study identified discrete host responses to typical bacterial, atypical bacterial and viral aetiologies of pneumonia in mice. These signatures validated well in humans, highlighting the conserved nature of the host response to these pathogen classes.
Sections du résumé
BACKGROUND
BACKGROUND
Pneumonia due to typical bacterial, atypical bacterial and viral pathogens can be difficult to clinically differentiate. Host response-based diagnostics are emerging as a complementary diagnostic strategy to pathogen detection.
METHODS
METHODS
We used murine models of typical bacterial, atypical bacterial and viral pneumonia to develop diagnostic signatures and understand the host's response to these types of infections. Mice were intranasally inoculated with
RESULTS
RESULTS
Mice infected with
DISCUSSION
CONCLUSIONS
This study identified discrete host responses to typical bacterial, atypical bacterial and viral aetiologies of pneumonia in mice. These signatures validated well in humans, highlighting the conserved nature of the host response to these pathogen classes.
Identifiants
pubmed: 39097412
pii: 11/1/e002001
doi: 10.1136/bmjresp-2023-002001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.