Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 Aug 2024
03 Aug 2024
Historique:
received:
14
02
2024
accepted:
23
07
2024
medline:
4
8
2024
pubmed:
4
8
2024
entrez:
3
8
2024
Statut:
epublish
Résumé
Low muscle mass is associated with numerous adverse outcomes independent of other associated comorbid diseases. We aimed to predict and understand an individual's risk for developing low muscle mass using proteomics and machine learning. We identified eight biomarkers associated with low pectoralis muscle area (PMA). We built three random forest classification models that used either clinical measures, feature selected biomarkers, or both to predict development of low PMA. The area under the receiver operating characteristic curve for each model was: clinical-only = 0.646, biomarker-only = 0.740, and combined = 0.744. We displayed the heterogenetic nature of an individual's risk for developing low PMA and identified two distinct subtypes of participants who developed low PMA. While additional validation is required, our methods for identifying and understanding individual and group risk for low muscle mass could be used to enable developments in the personalized prevention of low muscle mass.
Identifiants
pubmed: 39097658
doi: 10.1038/s41598-024-68447-y
pii: 10.1038/s41598-024-68447-y
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17981Subventions
Organisme : NHLBI NIH HHS
ID : T32HL105346
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32HL007633
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL116931
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08HL145118
Pays : United States
Investigateurs
Nicola A Hanania
(NA)
Mustafa Atik
(M)
Laura Bertrand
(L)
Aladin Boriek
(A)
Thomas Monaco
(T)
Dharani Narendra
(D)
Francesca Polverino
(F)
Veronica V Lenge de Rosen
(VVL)
Paula Sierra Salas
(PS)
Tianshi David Wu
(TD)
Dawn L DeMeo
(DL)
Craig P Hersh
(CP)
Alejandro A Diaz
(AA)
Staci M Gagne
(SM)
Francine L Jacobson
(FL)
Kathryn Marentette
(K)
George R Washko
(GR)
Seth Wilson
(S)
Jeong H Yun
(JH)
R Graham Barr
(RG)
John H M Austin
(JHM)
Maria Lorena Gomez Blum
(MLG)
Belinda M D'Souza
(BM)
Emilay Florez
(E)
Valeria Lopez
(V)
Wanda Pecheco
(W)
Byron Thomashow
(B)
Chris H Wendt
(CH)
Arianne Baldomero
(A)
Miranda Hassler
(M)
Ken M Kunisaki
(KM)
David MacDonald
(D)
Charlene McEvoy
(C)
Nell Adams
(N)
Barbara Heinz
(B)
Jonathan Phelan
(J)
Cheryl Sasse
(C)
Eric L Flenaugh
(EL)
Judith Delancy
(J)
Marilyn G Foreman
(MG)
Hirut Gebrekristos
(H)
Willi Howell
(W)
Dominique Lawson
(D)
Mario Ponce
(M)
Gloria Westney
(G)
Russell P Bowler
(RP)
Sophia Addi
(S)
Elena Engel
(E)
Jay Finigan
(J)
Claire Guo
(C)
Seth Kligerman
(S)
David A Lynch
(DA)
Elizabeth Regan
(E)
Lisa Ruvuna
(L)
Richard Rosiello
(R)
Jean Champagne
(J)
Mary Charpentier
(M)
Theodore Girard
(T)
Jon Jaksha
(J)
Diane Kirk
(D)
Laurie Kuck
(L)
Mohammed Quraishi
(M)
Lucia Sears
(L)
Gerard J Criner
(GJ)
Elise Cortese
(E)
Chandra Dass
(C)
Laurie Jameson
(L)
Nathaniel Marchetti
(N)
Francine McGonagle
(F)
Lauren Miller
(L)
Kim Selwood
(K)
Kartik Shenoy
(K)
Regina Sheridan
(R)
Shubhra Srivastava-Malhotra
(S)
Surya P Bhatt
(SP)
William C Bailey
(WC)
Sandeep Bodduluri
(S)
Joe W Chiles
(JW)
Mark T Dransfield
(MT)
Scott Grumley
(S)
Sonya Hardy
(S)
Anand Iyer
(A)
David C LaFon
(DC)
Padma Manapragada
(P)
Merry-Lynn McDonald
(ML)
Hrudaya Nath
(H)
Gabriela Oates
(G)
Satinder P Singh
(SP)
Raymond C Wade
(RC)
Mike Wells
(M)
Abigail West
(A)
Douglas Conrad
(D)
Jeffrey Barry
(J)
Marissa Gil
(M)
Albert Hsiao
(A)
Amber Martineau
(A)
Jenna Mielke
(J)
Gabriel Querido
(G)
Xavier Soler
(X)
Rajat Suri
(R)
Sean Swenson
(S)
Angela Wang
(A)
Andrew Yen
(A)
Alejandro Comellas
(A)
Eric Bruening
(E)
Sidney Davis
(S)
Nick Feeley
(N)
Spyridon Fortis
(S)
Devon Foster
(D)
Eric Garcia
(E)
Kaitlyn Glosser
(K)
Karin F Hoth
(KF)
Justin D Kuhn
(JD)
Archana Laroia
(A)
Changhyun Lee
(C)
Jeni Michelson
(J)
Kim Sprenger
(K)
Katelyn Wilensky
(K)
Alejandro Comellas
(A)
Eric Bruening
(E)
Sidney Davis
(S)
Nick Feeley
(N)
Spyridon Fortis
(S)
Devon Foster
(D)
Eric Garcia
(E)
Kaitlyn Glosser
(K)
Karin F Hoth
(KF)
Justin D Kuhn
(JD)
Archana Laroia
(A)
Changhyun Lee
(C)
Jeni Michelson
(J)
Kim Sprenger
(K)
Katelyn Wilensky
(K)
MeiLan K Han
(MK)
Gretchen Bautista
(G)
Jeffrey L Curtis
(JL)
Crystal Cutlip
(C)
Craig J Galban
(CJ)
Jaide Hawn
(J)
Ella Kazerooni
(E)
Wassim Labaki
(W)
Lisa McCloskey
(L)
Kelly Rysso
(K)
Liujian Zhao
(L)
Joanne Billings
(J)
Tadashi L Allen
(TL)
Mary P Bailey
(MP)
Anne Duesterbeck
(A)
Nate Gaeckle
(N)
Brooke Noren
(B)
Kyong Yun
(K)
Frank Sciurba
(F)
Daniel Arminavage
(D)
P Takis Benos
(PT)
Jessica Bon
(J)
Divay Chandra
(D)
Paula Consolaro
(P)
Tiffany Ditter
(T)
Jason Duin
(J)
Robert Gregg
(R)
Chad Karoleski
(C)
Zehavit Kirshenboim
(Z)
Rhonda Lincoln
(R)
Antonio Anzueto
(A)
Sandra G Adams
(SG)
Diego Maselli-Caceres
(D)
Mario E Ruiz
(ME)
Informations de copyright
© 2024. The Author(s).
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