Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza.


Journal

NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863

Informations de publication

Date de publication:
03 Aug 2024
Historique:
received: 05 12 2023
accepted: 17 07 2024
medline: 4 8 2024
pubmed: 4 8 2024
entrez: 3 8 2024
Statut: epublish

Résumé

This study reports on the immunogenicity and biodistribution of H5 hemagglutinin (HA)-based self-amplifying (sa) mRNA vaccines in mice. Four sa-mRNA vaccines encoding either a secreted full-length HA, a secreted HA head domain, a secreted HA stalk domain, or a full-length membrane-anchored HA were investigated. All vaccines elicited an adaptive immune response. However, the full-length HA sa-RNA vaccines demonstrated superior performance compared to head and stalk domain vaccines. The antibody titers positively correlated with the vaccine dose. Cellular immune responses and antigen-specific IgA antibodies in the lungs were also observed. The comparison of the sa-mRNA vaccines encoding the secreted and membrane-anchored full-length HA revealed that anchoring of the HA to the membrane significantly enhanced the antibody and cellular responses. In addition to the injection site, the intramuscularly injected sa-mRNA-LNPs were also detected in the draining lymph nodes, spleen, and to a lesser extent, in the lung, kidney, liver, and heart.

Identifiants

pubmed: 39097672
doi: 10.1038/s41541-024-00932-x
pii: 10.1038/s41541-024-00932-x
doi:

Types de publication

Journal Article

Langues

eng

Pagination

138

Subventions

Organisme : Bijzonder Onderzoeksfonds (Special Research Fund)
ID : BOF.BAS.2018.0028.01
Organisme : China Scholarship Council (CSC)
ID : 202107650043
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 1172121N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 12K0323N

Informations de copyright

© 2024. The Author(s).

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Auteurs

Xiaole Cui (X)

Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, B-9820, Merelbeke, Belgium.

Pieter Vervaeke (P)

Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, B-9820, Merelbeke, Belgium.

Ya Gao (Y)

Department of Translational Physiology, Infectiology and Public Health, Ghent University, B-9820, Merelbeke, Belgium.

Lisa Opsomer (L)

Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, B-9820, Merelbeke, Belgium.

Qing Sun (Q)

Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, B-9820, Merelbeke, Belgium.

Janne Snoeck (J)

Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, B-9820, Merelbeke, Belgium.

Bert Devriendt (B)

Department of Translational Physiology, Infectiology and Public Health, Ghent University, B-9820, Merelbeke, Belgium.

Zifu Zhong (Z)

Department of Pharmaceutics, Ghent University, Ghent, Belgium. zifu.zhong@ugent.be.
Cancer Research Institute (CRIG), Ghent University, 9000, Ghent, Belgium. zifu.zhong@ugent.be.

Niek N Sanders (NN)

Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, B-9820, Merelbeke, Belgium. niek.sanders@ugent.be.
Cancer Research Institute (CRIG), Ghent University, 9000, Ghent, Belgium. niek.sanders@ugent.be.

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