Distance-depending transcriptome changes of pancreatic stellate cells in paracrine pancreatic ductal adenocarcinoma co-culture models.
Pancreatic Stellate Cells
/ metabolism
Coculture Techniques
Carcinoma, Pancreatic Ductal
/ genetics
Animals
Mice
Pancreatic Neoplasms
/ genetics
Transcriptome
Paracrine Communication
Gene Expression Regulation, Neoplastic
Cell Line, Tumor
Humans
Cancer-Associated Fibroblasts
/ metabolism
Gene Expression Profiling
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 Aug 2024
04 Aug 2024
Historique:
received:
10
02
2024
accepted:
19
07
2024
medline:
5
8
2024
pubmed:
5
8
2024
entrez:
4
8
2024
Statut:
epublish
Résumé
Pancreatic stellate cells (PSC) are one source of cancer-associated fibroblasts (CAF) and play, therefore, an essential role in pancreatic ductal adenocarcinoma (PDA). Paracrine signalling between PDA cells and CAF has been widely studied, yet external influences on paracrine crosstalk are poorly understood. This study aimed to gain a deeper insight into the communication of PSC and cancer cells under different co-culture conditions via analysis of PSC gene expression profiles. Two contactless co-culture models with tumor cells from the p48-Cre; lox-stop-lox-Kras
Identifiants
pubmed: 39098880
doi: 10.1038/s41598-024-68148-6
pii: 10.1038/s41598-024-68148-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18030Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 449501615
Informations de copyright
© 2024. The Author(s).
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