Clinical and pathological characteristics of blastoid mantle cell lymphoma: a single institution experience.
Mantle cell lymphoma
blastoid
cyclin D1
lymphoma
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2024
2024
Historique:
accepted:
24
07
2024
medline:
5
8
2024
pubmed:
5
8
2024
entrez:
5
8
2024
Statut:
epublish
Résumé
Blastoid mantle cell lymphoma (B-MCL) is a rare aggressive lymphoma. It is characterized by blastoid morphology with high proliferation and inconsistent immunohistochemistry (IHC), making it a diagnostic challenge for the pathologist. This is a retrospective analytical cohort study. We reviewed biopsy confirmed cases of B-MCL diagnosed over a period of 10 years (January 2012 to December 2022). The clinical presentation, histopathological and IHC findings, treatment received, and survival outcomes were studied. Randomly selected cases of classic MCL (n=12), diagnosed during the same period served as controls. A total of 12 cases were studied. Four cases were transformed from previously diagnosed MCL; 8 cases arose There are several factors that contribute to the aggressiveness of B-MCL, and new treatment approaches might be required to improve patient outcomes.
Sections du résumé
Background
UNASSIGNED
Blastoid mantle cell lymphoma (B-MCL) is a rare aggressive lymphoma. It is characterized by blastoid morphology with high proliferation and inconsistent immunohistochemistry (IHC), making it a diagnostic challenge for the pathologist.
Methods
UNASSIGNED
This is a retrospective analytical cohort study. We reviewed biopsy confirmed cases of B-MCL diagnosed over a period of 10 years (January 2012 to December 2022). The clinical presentation, histopathological and IHC findings, treatment received, and survival outcomes were studied. Randomly selected cases of classic MCL (n=12), diagnosed during the same period served as controls.
Results
UNASSIGNED
A total of 12 cases were studied. Four cases were transformed from previously diagnosed MCL; 8 cases arose
Conclusion
UNASSIGNED
There are several factors that contribute to the aggressiveness of B-MCL, and new treatment approaches might be required to improve patient outcomes.
Identifiants
pubmed: 39099606
doi: 10.12688/f1000research.149582.2
pmc: PMC11297385
doi:
Banques de données
figshare
['10.6084/m9.figshare.25437115.v3']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
525Informations de copyright
Copyright: © 2024 Monappa V et al.
Déclaration de conflit d'intérêts
No competing interests were disclosed.