Decreased expression of p53 is associated with down expression of zyxin in breast cancer.
breast cancer
p53
zyxin
Journal
Health science reports
ISSN: 2398-8835
Titre abrégé: Health Sci Rep
Pays: United States
ID NLM: 101728855
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
09
01
2024
revised:
11
07
2024
accepted:
18
07
2024
medline:
5
8
2024
pubmed:
5
8
2024
entrez:
5
8
2024
Statut:
epublish
Résumé
Breast cancer (BC) is considered one of the most common malignant tumors leading to death in women, and genetic factors have a crucial role in BC pathogenesis. Zyxin (ZYX) is one of these factors that may be important in p53 level and function. Thus, the present work aimed to investigate the ZYX gene and protein expression in tumor tissue and matched margin tissue and its correlation with the p53 expression. In a present case-control study, 30 tumors and 30 matched margin tissues were obtained from Iran Tumor Bank/Tehran University of Medical Sciences. Real-time polymerase chain reaction and western blot analysis techniques were applied to evaluate the genes and protein expression, respectively. The data showed that expression of the ZYX gene in tumor tissues significantly decreased ( Based on our observation, ZYX might have a tumor suppressor role and is associated with p53.
Sections du résumé
Background and Aims
UNASSIGNED
Breast cancer (BC) is considered one of the most common malignant tumors leading to death in women, and genetic factors have a crucial role in BC pathogenesis. Zyxin (ZYX) is one of these factors that may be important in p53 level and function. Thus, the present work aimed to investigate the ZYX gene and protein expression in tumor tissue and matched margin tissue and its correlation with the p53 expression.
Methods
UNASSIGNED
In a present case-control study, 30 tumors and 30 matched margin tissues were obtained from Iran Tumor Bank/Tehran University of Medical Sciences. Real-time polymerase chain reaction and western blot analysis techniques were applied to evaluate the genes and protein expression, respectively.
Results
UNASSIGNED
The data showed that expression of the ZYX gene in tumor tissues significantly decreased (
Conclusion
UNASSIGNED
Based on our observation, ZYX might have a tumor suppressor role and is associated with p53.
Identifiants
pubmed: 39100715
doi: 10.1002/hsr2.2288
pii: HSR22288
pmc: PMC11294437
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e2288Informations de copyright
© 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.