Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation.
Journal
Bone research
ISSN: 2095-4700
Titre abrégé: Bone Res
Pays: China
ID NLM: 101608652
Informations de publication
Date de publication:
05 Aug 2024
05 Aug 2024
Historique:
received:
17
09
2023
accepted:
09
05
2024
revised:
03
04
2024
medline:
6
8
2024
pubmed:
6
8
2024
entrez:
5
8
2024
Statut:
epublish
Résumé
Apoptosis is crucial for tissue homeostasis and organ development. In bone, apoptosis is recognized to be a main fate of osteoblasts, yet the relevance of this process remains underexplored. Using our murine model with inducible Caspase 9, the enzyme that initiates intrinsic apoptosis, we triggered apoptosis in a proportion of mature osteocalcin (OCN
Identifiants
pubmed: 39103355
doi: 10.1038/s41413-024-00341-9
pii: 10.1038/s41413-024-00341-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
43Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : AR077539
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : CA093900
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : AR069620
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : APP1143802
Informations de copyright
© 2024. The Author(s).
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