Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment.
Epigenetics
Gestational age
Methylation
Neonatal
Perinatal
Preterm
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 Aug 2024
05 Aug 2024
Historique:
received:
08
03
2024
accepted:
19
07
2024
medline:
6
8
2024
pubmed:
6
8
2024
entrez:
5
8
2024
Statut:
epublish
Résumé
The time from conception through the first year of life is the most dynamic period in human development. This time period is particularly important for infants born very preterm (< 30 weeks gestation; VPT), as they experience a significant disruption in the normal developmental trajectories and are at heightened risk of experiencing developmental impairments and delays. Variations in the epigenetic landscape during this period may reflect this disruption and shed light on the interrelationships between aging, maturation, and the epigenome. We evaluated how gestational age (GA) and age since conception in neonates [post-menstrual age (PMA)], were related to DNA methylation in buccal cells collected at NICU discharge from VPT infants (n = 538). After adjusting for confounders and applying Bonferroni correction, we identified 2,366 individual CpGs associated with GA and 14,979 individual CpGs associated with PMA, as well as multiple differentially methylated regions. Pathway enrichment analysis identified pathways involved in axonogenesis and regulation of neuron projection development, among many other growth and developmental pathways (FDR q < 0.001). Our findings align with prior work, and also identify numerous novel associations, suggesting that genes important in growth and development, particularly neurodevelopment, are subject to substantial epigenetic changes during early development among children born VPT.
Identifiants
pubmed: 39103365
doi: 10.1038/s41598-024-68071-w
pii: 10.1038/s41598-024-68071-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18147Subventions
Organisme : National Institute of Child Health and Human Development
ID : K01MH129510
Organisme : National Institute of Child Health and Human Development
ID : R01HD072267
Organisme : National Institute of Child Health and Human Development
ID : R01HD084515
Organisme : National Institute of Child Health and Human Development
ID : R01HD084515
Organisme : NIEHS NIH HHS
ID : P30 ES019776
Pays : United States
Informations de copyright
© 2024. The Author(s).
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