Co-targeting SOS1 enhances the antitumor effects of KRAS


Journal

Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119

Informations de publication

Date de publication:
05 Aug 2024
Historique:
received: 23 01 2023
accepted: 08 07 2024
medline: 6 8 2024
pubmed: 6 8 2024
entrez: 5 8 2024
Statut: aheadofprint

Résumé

Combination approaches are needed to strengthen and extend the clinical response to KRAS

Identifiants

pubmed: 39103541
doi: 10.1038/s43018-024-00800-6
pii: 10.1038/s43018-024-00800-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Österreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency)
ID : 861507
Organisme : Österreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency)
ID : 867897
Organisme : Österreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency)
ID : 874517
Organisme : Österreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency)
ID : 883626
Organisme : Österreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency)
ID : 892584

Informations de copyright

© 2024. The Author(s).

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Auteurs

Venu Thatikonda (V)

Boehringer Ingelheim RCV, Vienna, Austria. vthatikonda@exscientia.co.uk.
Exscientia, Vienna, Austria. vthatikonda@exscientia.co.uk.

Hengyu Lyu (H)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Sabine Jurado (S)

Boehringer Ingelheim RCV, Vienna, Austria.

Kaja Kostyrko (K)

Boehringer Ingelheim RCV, Vienna, Austria.

Christopher A Bristow (CA)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Christoph Albrecht (C)

Boehringer Ingelheim RCV, Vienna, Austria.

Donat Alpar (D)

Boehringer Ingelheim RCV, Vienna, Austria.

Heribert Arnhof (H)

Boehringer Ingelheim RCV, Vienna, Austria.

Oliver Bergner (O)

Boehringer Ingelheim RCV, Vienna, Austria.

Karin Bosch (K)

Boehringer Ingelheim RCV, Vienna, Austria.

Ningping Feng (N)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Sisi Gao (S)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Daniel Gerlach (D)

Boehringer Ingelheim RCV, Vienna, Austria.

Michael Gmachl (M)

Boehringer Ingelheim RCV, Vienna, Austria.

Melanie Hinkel (M)

Boehringer Ingelheim RCV, Vienna, Austria.

Simone Lieb (S)

Boehringer Ingelheim RCV, Vienna, Austria.

Astrid Jeschko (A)

Boehringer Ingelheim RCV, Vienna, Austria.

Annette A Machado (AA)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Thomas Madensky (T)

Boehringer Ingelheim RCV, Vienna, Austria.

Ethan D Marszalek (ED)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mikhila Mahendra (M)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Gabriella Melo-Zainzinger (G)

Boehringer Ingelheim RCV, Vienna, Austria.

Jessica M Molkentine (JM)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Philipp A Jaeger (PA)

Boehringer Ingelheim RCV, Vienna, Austria.

David H Peng (DH)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Robyn L Schenk (RL)

Boehringer Ingelheim RCV, Vienna, Austria.

Alexey Sorokin (A)

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Sandra Strauss (S)

Boehringer Ingelheim RCV, Vienna, Austria.

Francesca Trapani (F)

Boehringer Ingelheim RCV, Vienna, Austria.

Scott Kopetz (S)

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Christopher P Vellano (CP)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mark Petronczki (M)

Boehringer Ingelheim RCV, Vienna, Austria.

Norbert Kraut (N)

Boehringer Ingelheim RCV, Vienna, Austria.

Timothy P Heffernan (TP)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Joseph R Marszalek (JR)

Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mark Pearson (M)

Boehringer Ingelheim RCV, Vienna, Austria.

Irene C Waizenegger (IC)

Boehringer Ingelheim RCV, Vienna, Austria.

Marco H Hofmann (MH)

Boehringer Ingelheim RCV, Vienna, Austria. marco.hofmann@boehringer-ingelheim.com.

Classifications MeSH