COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects.
COVID-19
Gender equity
Pandemics
Women
Women’s role
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
06 Aug 2024
06 Aug 2024
Historique:
received:
24
06
2024
accepted:
23
07
2024
medline:
6
8
2024
pubmed:
6
8
2024
entrez:
5
8
2024
Statut:
aheadofprint
Résumé
Despite the growing interest in gender medicine, the influence of sex and gender on human diseases, including stroke, continues to be underestimated and understudied. The COVID-19 pandemic has overall impacted not only the occurrence and management of stroke but has also exacerbated sex and gender disparities among both patients and healthcare providers. This paper aims to provide an updated overview on the influence of sex and gender in stroke pathophysiology and care during COVID-19 pandemic, through biological, clinical, psychosocial and research perspectives. Gender equity and awareness of the importance of sexual differences are sorely needed, especially in times of health crisis but have not yet been achieved to date. To this purpose, the sudden yet worldwide diffusion of COVID-19 represents a unique learning experience that highlights critical unmet needs also in gender medicine. The failures of this recent past should be kept as food for thought to inspire proper strategies reducing inequalities and to address women's health and wellbeing issues, particularly in case of future pandemics.
Identifiants
pubmed: 39103735
doi: 10.1007/s10072-024-07716-0
pii: 10.1007/s10072-024-07716-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. Fondazione Società Italiana di Neurologia.
Références
Rexrode KM, Madsen TE, Yu AYX et al (2022) The impact of sex and gender on stroke. Circ Res 130(4):512–528
pubmed: 35175851
pmcid: 8890686
Cordonnier C, Sprigg N, Sandset EC et al (2017) Women Initiative for Stroke in Europe (WISE) group. Stroke in women - from evidence to inequalities. Nat Rev Neurol 13(9):521–532
pubmed: 28731036
Altersberger VL, Stolze LJ, Heldner MR et al (2021) Maintenance of Acute Stroke Care Service during the COVID-19 pandemic lockdown. Stroke 52(5):1693–1701
pubmed: 33793320
pmcid: 8078117
Bersano A, Pantoni L (2021) Stroke care in Italy at the time of the COVID-19 pandemic: a lesson to learn. J Neurol 268(7):2307–2313
pubmed: 32954445
Brady E, Nielsen MW, Andersen JP et al (2021) Lack of consideration of sex and gender in COVID-19 clinical studies. Nat Commun 12(1):4015
pubmed: 34230477
pmcid: 8260641
Bucciarelli V, Nasi M, Bianco F et al (2022) Depression pandemic and cardiovascular risk in the COVID-19 era and long COVID syndrome: gender makes a difference. Trends Cardiovasc Med 32(1):12–17
pubmed: 34619336
Peckham H, de Gruijter NM, Raine C et al (2020) Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun 11(1):6317
pubmed: 33298944
pmcid: 7726563
Tadiri CP, Gisinger T, Kautzy-Willer A, GOING-FWD Consortium et al (2020) The influence of sex and gender domains on COVID-19 cases and mortality. CMAJ 192(36):E1041–E1045
pubmed: 32900766
pmcid: 7504881
Qureshi AI, Baskett WI, Huang W et al (2021) Acute ischemic stroke and COVID-19: an analysis of 27 676 patients. Stroke 52(3):905–912
pubmed: 33535779
pmcid: 7903982
Logroscino G, Beghi E (2021) Stroke epidemiology and COVID-19 pandemic. Curr Opin Neurol 34(1):3–10
pubmed: 33278139
Tsivgoulis G, Palaiodimou L, Zand R et al (2020) COVID-19 and cerebrovascular diseases: a comprehensive overview. Ther Adv Neurol Disord 13:1756286420978004
pubmed: 33343709
pmcid: 7727052
Ntaios G, Michel P, Georgiopoulos G et al (2020) Characteristics and outcomes in patients with COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry. Stroke 51(9):e254–e258
pubmed: 32787707
Martí-Fàbregas J, Guisado-Alonso D, Delgado-Mederos R et al (2021) Impact of COVID-19 infection on the outcome of patients with ischemic stroke. Stroke 52(12):3908–3917
pubmed: 34455823
pmcid: 8607902
Zedde M, Pezzella FR, Paciaroni M et al (2020) Stroke care in Italy: an overview of strategies to manage acute stroke in COVID-19 time. Eur Stroke J 5(3):222–229
pubmed: 33072875
pmcid: 7538763
Fraiman P, Godeiro Junior C, Moro E et al (2020) COVID-19 and Cerebrovascular diseases: a systematic review and perspectives for Stroke Management. Front Neurol 11:574694
pubmed: 33250845
pmcid: 7674955
Zuin M, Mazzitelli M, Rigatelli G et al (2023) Risk of ischemic stroke in patients recovered from COVID-19 infection: a systematic review and meta-analysis. Eur Stroke J 8(4):915–922
pubmed: 37491810
pmcid: 10372514
Mauvais-Jarvis F, Bairey Merz N, Barnes PJ et al (2020) Sex and gender: modifiers of health, disease, and medicine. Lancet 396(10250):565–582
pubmed: 32828189
pmcid: 7440877
NIH (2023) Putting science to work for the health of women. https://orwh.od.nih.gov/sex-gender ; access date
Strong B, Pudar J, Thrift AG et al (2021) Sex disparities in enrollment in recent randomized clinical trials of Acute Stroke: a Meta-analysis. JAMA Neurol 78(6):666–677
pubmed: 33900363
Bushnell CD, Chaturvedi S, Gage KR et al (2018) Sex differences in stroke: challenges and opportunities. J Cereb Blood Flow Metab 38(12):2179–2191
pubmed: 30114967
pmcid: 6282222
Liu M, Li G, Tang J et al (2018) The influence of sex in stroke thrombolysis: a systematic review and Meta-analysis. J Clin Neurol 14(2):141–152
pubmed: 29629522
pmcid: 5897195
Kapral MK, Fang J, Hill MD et al (2005) Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke 36(4):809–814
pubmed: 15731476
Sheth SA, Lee S, Warach SJ et al (2019) Sex differences in Outcome after Endovascular Stroke Therapy for Acute ischemic stroke. Stroke 50(9):2420–2427
pubmed: 31412752
pmcid: 6710145
Lakbar I, Luque-Paz D, Mege JL et al (2020) COVID-19 gender susceptibility and outcomes: a systematic review. PLoS ONE 15(11):e0241827
pubmed: 33141872
pmcid: 7608911
Marik PE, DePerrior SE, Ahmad Q et al (2021 Mar) Gender-based disparities in COVID-19 patient outcomes. J Investig Med 12:jim–2020
Schiffer VMMM, Janssen EBNJ, van Bussel BCT et al (2020) The sex gap in COVID-19 trials: a scoping review. EClinicalMedicine 29:100652
pubmed: 33283178
Richardson S, Hirsch JS, Narasimhan M et al (2020) Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA 323(20):2052–2059
pubmed: 32320003
pmcid: 7177629
National Center for Health Statistics ( https://www.cdc.gov/nchs/nhis/ADULTS/www/index.htm)
GBD 2017 DALYs and, Collaborators HALE (2018) Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the global burden of Disease Study 2017. Lancet 392(10159):1859–1922
Huang B, Cai Y, Li N et al (2021) Sex-based clinical and immunological differences in COVID-19. BMC Infect Dis 21(1):647
pubmed: 34225644
pmcid: 8256650
Torjesen I (2021) Covid-19: Middle aged women face greater risk of debilitating long term symptoms. BMJ 372:n829
pubmed: 33766927
Evans RA, McAuley H, Harrison EM, PHOSP-COVID Collaborative Group et al (2021) Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK Multicentre, prospective cohort study. Lancet Respir Med 9(11):1275–1287
pubmed: 34627560
pmcid: 8497028
Sigfrid L, Cevik M, Jesudason E et al (2021) What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol. BMJ Open 11(3):e043887
pubmed: 33692181
Burki T (2020) The indirect impact of COVID-19 on women. Lancet Infect Dis 20(8):904–905
pubmed: 32738239
pmcid: 7836874
News European Parliament (2023) https://www.europarl.europa.eu/news/en/headlines/society/20210225STO98702/understanding-the-impact-of-covid-19-on-women-infographics ; access date Oct
Gender Equality Index, European Institute for Gender Equality (2023) https://eige.europa.eu/gender-equality-index/2020 ; access date Oct
Boniol M, McIsaac M, Xu L et al (Oct 2023) Gender equity in the health workforce: analysis of 104 countries. World Health Organization. https://iris.who.int/bitstream/handle/10665/311314/WHO-HIS-HWF-Gender-WP1-2019.1-eng.pdf
Nguyen LH, Drew DA, Graham MS et al (2020) Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study. Lancet Public Health 5(9):e475–e483
pubmed: 32745512
pmcid: 7491202
United Nations P, Brief (2023) Oct., The impact of COVID-19 on women, https://unsdg.un.org/resources/policy-brief-impact-covid-19-women , access date
Bill and Melinda Gates foundation, Goalkeepers, Innovation and Inequity, Report (2021) https://www.gatesfoundation.org/goalkeepers/report/2021-report/?download=false&downloadYear=2021 , access date Oct. 2023
United, Nations (2023) Oct, Department of Economic and Social Affairs, Statistics, The world’s women 2020, Trends and statistic, https://www.un.org/en/desa/world%E2%80%99s-women-2020 , access date
Zhang Y, Xiao M, Zhang S et al (2020) Coagulopathy and Antiphospholipid Antibodies in patients with Covid-19. N Engl J Med 382(17):e38
pubmed: 32268022
Klok FA, Kruip MJHA, van der Meer NJM et al (2020) Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 191:145–147
pubmed: 32291094
pmcid: 7146714
Perry RJ, Smith CJ, Roffe C et al (2021) Characteristics and outcomes of COVID-19 associated stroke: a UK Multicentre case-control study. J Neurol Neurosurg Psychiatry 92(3):242–248
pubmed: 33154179
Holt A, Gislason GH, Schou M et al (2020) New-onset atrial fibrillation: incidence, characteristics, and related events following a national COVID-19 lockdown of 5.6 million people. Eur Heart J 41(32):3072–3079
pubmed: 32578859
Zhang T, Chen C, Xu X et al (2021) Impact of the COVID-19 pandemic and post-epidemic periods on the process of endovascular treatment for acute anterior circulation ischaemic stroke. BMC Neurol 21(1):238
pubmed: 34167467
pmcid: 8222699
Siepmann T, Sedghi A, Simon E et al (2021) Increased risk of acute stroke among patients with severe COVID-19: a multicenter study and meta-analysis. Eur J Neurol 28(1):238–247
pubmed: 32920964
Merkler AE, Parikh NS, Mir S et al (2020) Risk of ischemic stroke in patients with Coronavirus Disease 2019 (COVID-19) vs patients with influenza. JAMA Neurol 77(11):1–7
pubmed: 32614385
pmcid: 7333175
Majidi S, Fifi JT, Ladner TR et al (2020) Emergent large vessel occlusion stroke during New York City’s COVID-19 outbreak: clinical characteristics and paraclinical findings. Stroke 51(9):2656–2663
pubmed: 32755349
pmcid: 7434004
Trifan G, Goldenberg FD, Caprio FZ et al (2020) Characteristics of a diverse cohort of stroke patients with SARS-CoV-2 and Outcome by Sex. J Stroke Cerebrovasc Dis 29(11):105314
pubmed: 32951959
pmcid: 7486061
Margos NP, Meintanopoulos AS, Filioglou D et al (2021) Intracerebral hemorrhage in COVID-19: a narrative review. J Clin Neurosci 89:271–278
pubmed: 34119280
pmcid: 8096173
Ko JY, Danielson ML, Town M et al (2021) Risk factors for Coronavirus Disease 2019 (COVID-19)-Associated hospitalization: COVID-19-Associated Hospitalization Surveillance Network and behavioral risk factor Surveillance System. Clin Infect Dis 72(11):e695–e703
pubmed: 32945846
Baldini T, Asioli GM, Romoli M et al (2021) Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: a systematic review and meta-analysis. Eur J Neurol 28(10):3478–3490
pubmed: 33426733
Bilotta C, Perrone G, Adelfio V et al (2021) COVID-19 vaccine-related thrombosis: a systematic review and exploratory analysis. Front Immunol 12:729251
pubmed: 34912330
pmcid: 8666479
Rizk JG, Gupta A, Sardar P et al (2021) Clinical characteristics and Pharmacological Management of COVID-19 Vaccine-Induced Immune thrombotic Thrombocytopenia with cerebral venous sinus thrombosis: a review. JAMA Cardiol 6(12):1451–1460
pubmed: 34374713
Nogueira RG, Abdalkader M, Qureshi MM et al (2021) Global impact of COVID-19 on stroke care. Int J Stroke 16(5):573–584
pubmed: 33459583
pmcid: 8010375
Sodero A, Sarti C, Accavone D et al (2022) Impact of COVID-19 related lockdown measures on Stroke Care Quality in Careggi University Hospital, Florence. Theranostics Brain. Spine Neural Disord 4(3):555637
Katsanos AH, Palaiodimou L, Zand R et al (2021) Changes in Stroke Hospital Care during the COVID-19 pandemic: a systematic review and Meta-analysis. Stroke 52(11):3651–3660
pubmed: 34344166
pmcid: 8547579
Nogueira RG, Qureshi MM, Abdalkader M et al (2021) Global impact of COVID-19 on Stroke Care and IV Thrombolysis. Neurology 96(23):e2824–e2838
pubmed: 33766997
pmcid: 8205458
Sacco S, Ricci S, Ornello R et al (2020) Reduced admissions for cerebrovascular events during COVID-19 outbreak in Italy. Stroke 51(12):3746–3750
pubmed: 33059543
pmcid: 7678662
Aguiar de Sousa D, Sandset EC, Elkind MSV (2020) The curious case of the missing strokes during the COVID-19 pandemic. Stroke 51(7):1921–1923
pubmed: 32466737
John S, Hussain SI, Piechowski-Jozwiak B et al (2020) Clinical characteristics and admission patterns of stroke patients during the COVID 19 pandemic: a single center retrospective, observational study from the Abu Dhabi, United Arab Emirates. Clin Neurol Neurosurg 199:106227
pubmed: 33011516
pmcid: 7485577
Rudilosso S, Laredo C, Vera V et al (2020) Acute Stroke Care is at risk in the era of COVID-19: experience at a Comprehensive Stroke Center in Barcelona. Stroke 51(7):1991–1995
pubmed: 32438895
Siegler JE, Zha AM, Czap AL et al (2021) Influence of the COVID-19 Pandemic on Treatment Times for Acute Ischemic Stroke: The Society of Vascular and Interventional Neurology Multicenter Collaboration [published correction appears in Stroke. ;52(3):e104]. Stroke. 2021;52(1):40–47
Teo KC, Leung WCY, Wong YK et al (2020) Delays in stroke onset to hospital arrival time during COVID-19. Stroke 51(7):2228–2231
pubmed: 32432998
Brocard E, Antoine P, Mélihan-Cheinin P et al (2021) COVID-19’s impact on home health services, caregivers and patients: lessons from the French experience. Lancet Reg Health Eur 8:100197
pubmed: 34423328
pmcid: 8372449
Kar SK, Yasir Arafat SM, Kabir R et al (2020) Coping with Mental Health Challenges During COVID-19. Coronavirus Disease 2019 (COVID-19). ;199–213
Courtet P, Olié E, Debien C et al (2020) Keep socially (but not physically) connected and carry on: preventing suicide in the age of COVID-19. J Clin Psychiatry 81(3):20com13370
pubmed: 32297718
Salari N, Hosseinian-Far A, Jalali R et al (2020) Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis. Global Health 16(1):57
pubmed: 32631403
pmcid: 7338126
Xiong J, Lipsitz O, Nasri F et al (2020) Impact of COVID-19 pandemic on mental health in the general population: a systematic review. J Affect Disord 277:55–64
pubmed: 32799105
pmcid: 7413844
Bersano A, Pantoni L (2020) On being a neurologist in Italy at the time of the COVID-19 outbreak. Neurology 94(21):905–906
pubmed: 32245844
Bersano A, Kraemer M, Touzé E et al (2020) Stroke care during the COVID-19 pandemic: experience from three large European countries. Eur J Neurol 27(9):1794–1800
pubmed: 32492764
Buselli R, Corsi M, Baldanzi S et al (2020) Professional Quality of Life and Mental Health Outcomes among Health Care workers exposed to Sars-Cov-2 (Covid-19). Int J Environ Res Public Health 17(17):6180
pubmed: 32858810
pmcid: 7504107
Buselli R, Corsi M, Veltri A et al (2021) Mental health of Health Care workers (HCWs): a review of organizational interventions put in place by local institutions to cope with new psychosocial challenges resulting from COVID-19. Psychiatry Res 299:113847
pubmed: 33721785
pmcid: 7920813
Carmassi C, Pedrinelli V, Dell’Oste V et al (2021) Work and social functioning in frontline healthcare workers during the covid-19 pandemic in Italy: role of acute post-traumatic stress, depressive and anxiety symptoms. Riv Psichiatr 56(4):189–197
pubmed: 34310576
Pappa S, Ntella V, Giannakas T et al (2020) Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: a systematic review and meta-analysis. Brain Behav Immun 88:901–907
pubmed: 32437915
pmcid: 7206431
De Sio S, Buomprisco G, La Torre G et al (2020) The impact of COVID-19 on doctors’ well-being: results of a web survey during the lockdown in Italy. Eur Rev Med Pharmacol Sci 24(14):7869–7879
pubmed: 32744715
Ramaci T, Barattucci M, Ledda C et al (2020) Social Stigma during COVID-19 and its impact on HCWs outcomes. Sustainability 12(9):3834
Barbieri B, Balia S, Sulis I et al (2021) Don’t call it Smart: Working from Home during the Pandemic Crisis. Front Psychol 12:741585
pubmed: 34659060
pmcid: 8515044
Patel V, Saxena S, Lund C et al (2018) The Lancet Commission on global mental health and sustainable development. Lancet 392(10157):1553–1598
pubmed: 30314863
Firew T, Sano ED, Lee JW et al (2020) Protecting the front line: a cross-sectional survey analysis of the occupational factors contributing to healthcare workers’ infection and psychological distress during the COVID-19 pandemic in the USA. BMJ Open 10(10):e042752
pubmed: 33087382
pmcid: 7580061
Orsini A, Corsi M, Santangelo A et al (2020) Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients. Neurol Sci 41(9):2353–2366
pubmed: 32767055
pmcid: 7410516
Godderis L, Boone A, Bakusic J (2020) COVID-19: a new work-related disease threatening healthcare workers. Occup Med (Lond) 70(5):315–316
pubmed: 32359148
Lai J, Ma S, Wang Y et al (2020) Factors Associated with Mental Health Outcomes among Health Care workers exposed to Coronavirus Disease 2019. JAMA Netw Open 3(3):e203976
pubmed: 32202646
pmcid: 7090843
Pfefferbaum B, North CS (2020) Mental Health and the Covid-19 pandemic. N Engl J Med 383(6):510–512
pubmed: 32283003
Shanafelt T, Ripp J, Trockel M (2020) Understanding and addressing sources of anxiety among Health Care professionals during the COVID-19 pandemic. JAMA 323(21):2133–2134
pubmed: 32259193
Tan BYQ, Chew NWS, Lee GKH et al (2020) Psychological impact of the COVID-19 pandemic on Health Care Workers in Singapore. Ann Intern Med 173(4):317–320
pubmed: 32251513
Eberly LA, Kallan MJ, Julien HM et al (2020) Patient characteristics Associated with Telemedicine Access for primary and Specialty Ambulatory Care during the COVID-19 pandemic. JAMA Netw Open 3(12):e2031640
pubmed: 33372974
pmcid: 7772717
Ahmed H, Patel K, Greenwood DC et al (2020) Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: a systematic review and meta-analysis. J Rehabil Med 52(5):jrm00063
pubmed: 32449782
Hare DL, Toukhsati SR, Johansson P et al (2014) Depression and cardiovascular disease: a clinical review. Eur Heart J 35(21):1365–1372
pubmed: 24282187
Valtorta NK, Kanaan M, Gilbody S et al (2018) Loneliness, social isolation and risk of cardiovascular disease in the English Longitudinal Study of Ageing. Eur J Prev Cardiol 25(13):1387–1396
pubmed: 30068233
Backhouse EV, McHutchison CA, Cvoro V et al (2018) Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: a systematic review and meta-analysis. PLoS ONE 13(7):e0200525
pubmed: 30011299
pmcid: 6047794
Huang Y, Xu S, Hua J et al (2015) Association between job strain and risk of incident stroke: a meta-analysis. Neurology 85(19):1648–1654
pubmed: 26468409
Gronewold J, Engels M, van de Velde S et al (2021) Effects of Life events and social isolation on Stroke and Coronary Heart Disease. Stroke 52(2):735–747
pubmed: 33445957
Booth J, Connelly L, Lawrence M et al (2015) Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis. BMC Neurol 15:233
pubmed: 26563170
pmcid: 4643520
Gronewold J, Kropp R, Lehmann N et al (2020) Association of social relationships with incident cardiovascular events and all-cause mortality. Heart 106(17):1317–1323
pubmed: 32165451
Goeldlin MB, Wenz ES, Kottler C et al (2023) Connecting women in Neurosciences: a networking project to sustain mutual empowerment in young, female clinical neuroscientists. Eur J Neurol. Jun 17
Ross L, Hassett C, Brown P et al (2023) Gender representation among Physician authors of Practice guidelines developed, endorsed, or affirmed by the American Academy of Neurology. Neurology 100(5):e465–e472
pubmed: 35680419
Myers KR, Tham WY, Yin Y et al (2020) Unequal effects of the COVID-19 pandemic on scientists. Nat Hum Behav 4(9):880–883
pubmed: 32669671
National Academies of Sciences, Engineering, and Medicine; Policy and Global Affairs Committee on women in Science, Engineering, and Medicine; Committee on investigating the potential impacts of COVID-19 on the careers of women in Academic Science, Engineering, and Medicine, Dahlberg ML, Higginbotham E (eds) The impact of COVID-19 on the careers of women in Academic sciences, Engineering, and Medicine. Washington (DC): National Academies Press (US); March 9, 2021
Lyden PD (2020) Stroke, Research and Science in the time of COVID. Stroke 51(9):2613–2614
pubmed: 32755344
pmcid: 7446998
Reardon S (2021) Fewer citations for female authors of medical research [published online ahead of print, 2021 Jul 29]. Nature. ;10.1038/d41586-021-02102-8
Reardon S (2021) Pandemic measures disproportionately harm women’s careers. Nature. Mar 29
Cui R, Ding H, Zhu F (Jun 2020) Gender inequality in Research Productivity during the COVID-19 pandemic. Manufacturing & Service Operations Management, Forthcoming
Climie RE, Marques FZ (2020) Impact, strategies, and opportunities for Early and Midcareer Cardiovascular Researchers during the COVID-19 pandemic. Circulation 141(23):1838–1840
pubmed: 32286082
pmcid: 7314496
Climie RE, Wu JHY, Calkin AC et al (2020) Lack of Strategic Funding and Long-Term Job Security Threaten to have Profound effects on Cardiovascular researcher Retention in Australia. Heart Lung Circ 29(11):1588–1595
pubmed: 32839116
pmcid: 7442027
Weissgerber T, Bediako Y, de Winde CM et al (2020) Mitigating the impact of conference and travel cancellations on researchers’ futures. Elife. ;9:e57032
Termini CM, Traver D (2020) Impact of COVID-19 on early career scientists: an optimistic guide for the future. BMC Biol 18(1):95
pubmed: 32731867
pmcid: 7391227
King MM, Frederickson ME (January 2021) The pandemic penalty: the Gendered effects of COVID-19 on Scientific Productivity. Socius
Andersen JP, Nielsen MW, Simone NL et al (2020) COVID-19 medical papers have fewer women first authors than expected. Elife 9:e58807
pubmed: 32538780
pmcid: 7304994
Gayet-Ageron A, Ben Messaoud K, Richards M et al (2021) Female authorship of covid-19 research in manuscripts submitted to 11 biomedical journals: cross sectional study. BMJ 375:n2288
pubmed: 34615650
pmcid: 8493599
Adeoye O, Nyström KV, Yavagal DR et al (2019) Recommendations for the establishment of Stroke systems of Care: a 2019 Update. Stroke 50(7):e187–e210
pubmed: 31104615
Marson AG, Bassetti CLA (2020) EAN Congress highlights challenges - predict, prevent, repair. Nat Rev Neurol 16(8):401–402
pubmed: 32591755
pmcid: 7318902
Appelros P, Nydevik I, Viitanen M (2003) Poor outcome after first-ever stroke: predictors for death, dependency, and recurrent stroke within the first year. Stroke 34(1):122–126
pubmed: 12511762
Bots SH, Peters SAE, Woodward M (2017) Sex differences in coronary heart disease and stroke mortality: a global assessment of the effect of ageing between 1980 and 2010. BMJ Glob Health 2(2):e000298
pubmed: 28589033
pmcid: 5435266
Carcel C, Woodward M, Balicki G et al (2019) Trends in recruitment of women and reporting of sex differences in large-scale published randomized controlled trials in stroke. Int J Stroke 14(9):931–938
pubmed: 31132968
Wenham C, Smith J, Morgan R, Gender, COVID-19 Working Group (2020) COVID-19: the gendered impacts of the outbreak. Lancet 395(10227):846–848
pubmed: 32151325
pmcid: 7124625
Galbadage T, Peterson BM, Awada J et al (2020) Systematic review and Meta-analysis of sex-specific COVID-19 clinical outcomes. Front Med (Lausanne) 7:348
pubmed: 32671082
Santiago A, Dugarova E, UNDP, Staab S, Tabbush C (2021) Oct. (UN Women) COVID-19 Global Gender Response Tracker. https://data.undp.org/gendertracker/ , access date
Huang GC, Silver JK (2021) Women sidelined in pandemic research. BMJ 375:n2381
pubmed: 34615644
Rawlley B, Marchina S, Cappucci SP et al (2023) Investigation on gender differences in Leadership of Stroke-related clinical trials. Stroke 54(2):295–303
pubmed: 36300372