Velocity of cerebrospinal fluid in the aqueduct measured by phase-contrast MRI in rat.
aqueduct
cerebrospinal fluid
flow velocity
magnetic resonance imaging
rat
Journal
NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233
Informations de publication
Date de publication:
05 Aug 2024
05 Aug 2024
Historique:
revised:
15
04
2024
received:
31
10
2023
accepted:
22
07
2024
medline:
6
8
2024
pubmed:
6
8
2024
entrez:
6
8
2024
Statut:
aheadofprint
Résumé
Cerebrospinal fluid (CSF) circulation plays a key role in cerebral waste clearance via the glymphatic system. Although CSF flow velocity is an essential component of CSF dynamics, it has not been sufficiently characterized, and particularly, in studies of the glymphatic system in rat. To investigate the relationship between the flow velocity of CSF in the brain aqueduct and the glymphatic waste clearance rate, using phase-contrast MRI we performed the first measurements of CSF velocity in rats. Phase-contrast MRI was performed using a 7 T system to map mean velocity of CSF flow in the aqueduct in rat brain. The effects of age (3 months old versus 18 months old), gender, strain (Wistar, RNU, Dark Agouti), anesthetic agents (isoflurane versus dexmedetomidine), and neurodegenerative disorder (Alzheimer' disease in Fischer TgF344-AD rats, males and females) on CSF velocity were investigated in eight independent groups of rats (12 rats per group). Our results demonstrated that quantitative velocities of CSF flow in the aqueduct averaged 5.16 ± 0.86 mm/s in healthy young adult male Wistar rats. CSF flow velocity in the aqueduct was not altered by rat gender, strain, and the employed anesthetic agents in all rats, also age in the female rats. However, aged (18 months) Wistar male rats exhibited significantly reduced the CSF flow velocity in the aqueduct (4.31 ± 1.08 mm/s). In addition, Alzheimer's disease further reduced the CSF flow velocity in the aqueduct of male and female rats.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5233Subventions
Organisme : NIH HHS
ID : R01 NS108463
Pays : United States
Organisme : NIH HHS
ID : AG057494
Pays : United States
Organisme : NIH HHS
ID : R21 AG070173
Pays : United States
Informations de copyright
© 2024 The Author(s). NMR in Biomedicine published by John Wiley & Sons Ltd.
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