CD4
CSU
T cells
angioedema
chemokines
mast cells
wheals
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
14
11
2023
accepted:
09
07
2024
medline:
6
8
2024
pubmed:
6
8
2024
entrez:
6
8
2024
Statut:
epublish
Résumé
The proximity of activated T cells and mast cells in the lesional skin of patients with chronic spontaneous urticaria (CSU) is held to contribute to the development of wheals and angioedema. In a previous study, we demonstrated that increased IL-17 expression in T cells and mast cells in skin lesions of patients with CSU is associated with T/mast cell proximity, but the mechanisms that drive T cell/mast cell co-localization remain unknown. To assess if chemokines expressed in lesional CSU skin contribute to T cell/mast cell proximity. Biopsies from lesional CSU skin were compared to biopsies from healthy skin for expression of CCR5 and its ligand CCL3 by CD4 Numbers of CCR5-positive CD4 The close proximity of T cells and mast cells in the skin of severe CSU may be driven, at least in part by increased CCR5 and CCL3 expression. Therapies that target CCL3 interaction with CCR5 should be assessed for their effects in CSU.
Sections du résumé
Background
UNASSIGNED
The proximity of activated T cells and mast cells in the lesional skin of patients with chronic spontaneous urticaria (CSU) is held to contribute to the development of wheals and angioedema. In a previous study, we demonstrated that increased IL-17 expression in T cells and mast cells in skin lesions of patients with CSU is associated with T/mast cell proximity, but the mechanisms that drive T cell/mast cell co-localization remain unknown.
Objectives
UNASSIGNED
To assess if chemokines expressed in lesional CSU skin contribute to T cell/mast cell proximity.
Patients and methods
UNASSIGNED
Biopsies from lesional CSU skin were compared to biopsies from healthy skin for expression of CCR5 and its ligand CCL3 by CD4
Results
UNASSIGNED
Numbers of CCR5-positive CD4
Conclusions
UNASSIGNED
The close proximity of T cells and mast cells in the skin of severe CSU may be driven, at least in part by increased CCR5 and CCL3 expression. Therapies that target CCL3 interaction with CCR5 should be assessed for their effects in CSU.
Identifiants
pubmed: 39104520
doi: 10.3389/fimmu.2024.1327040
pmc: PMC11298339
doi:
Substances chimiques
Chemokine CCL3
0
Receptors, CCR5
0
CCR5 protein, human
0
CCL3 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1327040Informations de copyright
Copyright © 2024 Mubariki, Samara, Gimenez-Arnua, Maurer, Bejar, Toubi and Vadasz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.