Anatomical and electrophysiological analysis of the fasciola cinerea of the mouse hippocampus.
CA2
fasciola cinerea
hippocampal circuits
in‐vivo electrophysiology
juxtacellular recording‐labeling
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
06 Aug 2024
06 Aug 2024
Historique:
revised:
20
05
2024
received:
13
06
2023
accepted:
03
07
2024
medline:
6
8
2024
pubmed:
6
8
2024
entrez:
6
8
2024
Statut:
aheadofprint
Résumé
The hippocampus is considered essential for several forms of declarative memory, including spatial and social memory. Despite the extensive research of the classic subfields of the hippocampus, the fasciola cinerea (FC)-a medially located structure within the hippocampal formation-has remained largely unexplored. In the present study, we performed a morpho-functional characterization of principal neurons in the mouse FC. Using in vivo juxtacellular recording of single neurons, we found that FC neurons are distinct from neighboring CA1 pyramidal cells, both morphologically and electrophysiologically. Specifically, FC neurons displayed non-pyramidal morphology and granule cell-like apical dendrites. Compared to neighboring CA1 pyramidal neurons, FC neurons exhibited more regular in vivo firing patterns and a lower tendency to fire spikes at short interspike intervals. Furthermore, tracing experiments revealed that the FC receives inputs from the lateral but not the medial entorhinal cortex and CA3, and it provides a major intra-hippocampal projection to the septal CA2 and sparser inputs to the distal CA1. Overall, our results indicate that the FC is a morphologically and electrophysiologically distinct subfield of the hippocampal formation; given the established role of CA2 in social memory and seizure initiation, the unique efferent intra-hippocampal connectivity of the FC points to possible roles in social cognition and temporal lobe epilepsy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Werner Reichardt Centre for Integrative Neuroscience
ID : EXC 307
Organisme : Eberhard Karls University of Tübingen
ID : IntramuralFunding
Organisme : Eberhard Karls University of Tübingen
ID : Athene Grant
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : BU 3126/2-1
Informations de copyright
© 2024 The Author(s). Hippocampus published by Wiley Periodicals LLC.
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