Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions.
H3K4me3 epigenome
Nrf2 signaling
Wnt signaling pathway
cell fate decision
embryonic stem cells
mesendoderm
neuroectoderm
reactive oxygen species
redox
stem cell heterogeneity
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
30 Jul 2024
30 Jul 2024
Historique:
received:
22
12
2023
revised:
23
04
2024
accepted:
09
07
2024
medline:
7
8
2024
pubmed:
7
8
2024
entrez:
6
8
2024
Statut:
aheadofprint
Résumé
Pluripotent embryonic stem cells (ESCs) can develop into any cell type in the body. Yet, the regulatory mechanisms that govern cell fate decisions during embryogenesis remain largely unknown. We now demonstrate that mouse ESCs (mESCs) display large natural variations in mitochondrial reactive oxygen species (mitoROS) levels that individualize their nuclear redox state, H3K4me3 landscape, and cell fate. While mESCs with high mitoROS levels (mitoROS
Identifiants
pubmed: 39106861
pii: S1534-5807(24)00445-3
doi: 10.1016/j.devcel.2024.07.008
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.