Inhibitory fear memory engram in the mouse central lateral amygdala.

CP: Neuroscience GABAergic neurons activity-dependent labeling central amygdala chemogenetic electrophysiology fear memory synaptic inhibition synaptic plasticity

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
17 Jul 2024
Historique:
received: 04 01 2022
revised: 29 04 2024
accepted: 24 06 2024
medline: 7 8 2024
pubmed: 7 8 2024
entrez: 6 8 2024
Statut: aheadofprint

Résumé

Engrams, which are cellular substrates of memory traces, have been identified in various brain areas, including the amygdala. While most identified engrams are composed of excitatory, glutamatergic neurons, GABAergic inhibitory engrams have been relatively overlooked. Here, we report the identification of an inhibitory engram in the central lateral amygdala (CeL), a key area for auditory fear conditioning. This engram is primarily composed of GABAergic somatostatin-expressing (SST(+)) and, to a lesser extent, protein kinase C-δ-expressing (PKC-δ(+)) neurons. Fear memory is accompanied by a preferential enhancement of synaptic inhibition onto PKC-δ(+) neurons. Silencing this CeL GABAergic engram disinhibits the activity of targeted extra-amygdaloid areas, selectively increasing the expression of fear. Our findings define the behavioral function of an engram formed exclusively by GABAergic inhibitory neurons in the mammalian brain.

Identifiants

DOI: 10.1016/j.celrep.2024.114468 PMID: 39106862
pubmed: 39106862
pii: S2211-1247(24)00797-6
doi: 10.1016/j.celrep.2024.114468
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114468

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Wen-Hsien Hou (WH)

Department of Biomedicine, Aarhus University, Aarhus, Denmark; DANDRITE, The Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, Denmark; Center for Proteins in Memory - PROMEMO, Danish National Research Foundation, Aarhus University, Aarhus, Denmark.

Meet Jariwala (M)

Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Proteins in Memory - PROMEMO, Danish National Research Foundation, Aarhus University, Aarhus, Denmark.

Kai-Yi Wang (KY)

Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Anna Seewald (A)

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Yu-Ling Lin (YL)

Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Yi-Chen Liou (YC)

Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Alessia Ricci (A)

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Francesco Ferraguti (F)

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Cheng-Chang Lien (CC)

Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: cclien@nycu.edu.tw.

Marco Capogna (M)

Department of Biomedicine, Aarhus University, Aarhus, Denmark; DANDRITE, The Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, Denmark; Center for Proteins in Memory - PROMEMO, Danish National Research Foundation, Aarhus University, Aarhus, Denmark.

Classifications MeSH