SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.
Humans
Receptors, sigma
/ metabolism
Endoplasmic Reticulum Stress
Autophagy-Related Protein-1 Homolog
/ metabolism
Apoptosis
Sigma-1 Receptor
Autophagy
Cell Line, Tumor
Signal Transduction
AMP-Activated Protein Kinases
/ metabolism
Unfolded Protein Response
Intracellular Signaling Peptides and Proteins
/ metabolism
Mutation
31_50del
AMPK
C238T
ULK1
dHMN
σ1R
Journal
Functional & integrative genomics
ISSN: 1438-7948
Titre abrégé: Funct Integr Genomics
Pays: Germany
ID NLM: 100939343
Informations de publication
Date de publication:
07 Aug 2024
07 Aug 2024
Historique:
received:
19
04
2024
accepted:
30
07
2024
revised:
09
07
2024
medline:
7
8
2024
pubmed:
7
8
2024
entrez:
6
8
2024
Statut:
epublish
Résumé
Distal hereditary motor neuropathy (dHMN) is a progressive neurological disease characterized by distal limb muscle weakness and amyotrophy. Sigma 1 receptor (σ1R), a gene product of SIGMAR1, mutations have been reported to induce dHMN, but its mechanism remains unknown. This study aims to explore the effect of C238T and 31_50del mutations in σ1R on neuronal SH-SY5Y cell functions. The SH-SY5Y cells that overexpressed σ1R, C238T mutant σ1R (σ1R
Identifiants
pubmed: 39107544
doi: 10.1007/s10142-024-01414-y
pii: 10.1007/s10142-024-01414-y
doi:
Substances chimiques
Receptors, sigma
0
Autophagy-Related Protein-1 Homolog
EC 2.7.11.1
Sigma-1 Receptor
0
ULK1 protein, human
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Intracellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
134Subventions
Organisme : Natural Science Foundation of Hunan Provincial
ID : No. 2017JJ2365
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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