Mitigating effects of selenium and zinc on oxidative stress and biochemical and histopathological changes in lung during prenatal and lactational exposure rats to barium chloride.

Adult and suckling rats Barium chloride Collagen deposition Lung toxicity Selenium Zinc

Journal

Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769

Informations de publication

Date de publication:
06 Aug 2024
Historique:
received: 31 01 2024
accepted: 22 07 2024
medline: 7 8 2024
pubmed: 7 8 2024
entrez: 6 8 2024
Statut: aheadofprint

Résumé

Selenium (Se) and zinc (Zn) are essential trace elements with antioxidant properties, and their supplementation has been shown to be protective against the toxicity of various environmental and dietary substances. The aim of this study was to investigate the potential protective effect of selenium and zinc as adjuvants against barium (Ba) toxicity in lactating rats and their offspring. The pregnant rats were divided into six groups: the first as control; group 2 received barium (67 ppm) in the drinking water; group 3 had combined Ba + Se (0.5 mg/kg) in the diet; group 4 received Zn (50 mg/kg bw) by gavage together with Ba; groups 5 and 6, positive controls, were treated with selenium (0.5 mg/kg) and zinc (50 mg/kg bw), respectively. MDA, H

Identifiants

pubmed: 39107636
doi: 10.1007/s11356-024-34483-4
pii: 10.1007/s11356-024-34483-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Awatef Elwej (A)

Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia. awatefelwej@yahoo.fr.

Imen Ghorbel (I)

Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia.

Mariem Chaabane (M)

Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia.

Sabrine Chelly (S)

Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia.

Tahia Boudawara (T)

Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029, Sfax, Tunisia.

Najiba Zeghal (N)

Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia.

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