Salivary 8-hydroxy-2'-deoxyguanosine levels in patients with oral cancer: a systematic review and meta-analysis.

Humans 8-Hydroxy-2'-Deoxyguanosine / metabolism Mouth Neoplasms / metabolism Saliva / metabolism Oxidative Stress Biomarkers, Tumor / metabolism
8-hydroxy-2′-deoxyguanosine Biomarkers Saliva Squamous cell carcinoma of head and neck

Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
06 Aug 2024
Historique:
received: 08 06 2024
accepted: 01 08 2024
medline: 7 8 2024
pubmed: 7 8 2024
entrez: 6 8 2024
Statut: epublish

Résumé

DNA is an important target for oxidative attack and its modification may increase the risk of mutagenesis. The aim of this study was to evaluate and compare salivary levels of the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in patients with oral cancer (OC) compared to the control group by a comprehensive search of the available literature. The present systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and was registered in Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/X3YMR. Four electronic databases were used to identify studies for this systematic review: PubMed, Scopus, ScienceDirect, and Web of Science from January 15, 2005, to April 15, 2021. The Joanna Briggs Institute (JBI) tool was used to assess article quality. Of the 166 articles identified, 130 articles were excluded on the basis of title and abstract screening (duplicates, reviews, etc.). Thirty-six articles were evaluated at full text and 7 articles met the inclusion criteria. Of these, only 5 studies had compatible data for quantitative analysis. An increase in salivary 8-OHdG levels was found in patients with OC compared to healthy subjects, but without statistical significance. 8-OHdG: SMD = 2,72 (95%CI= -0.25-5.70); *p = 0.07. This systematic review and meta-analysis suggests a clear trend of increased 8-OHdG levels in saliva of OC patients compared to the control group. However, further studies are required to clarify and understand the altered levels of this oxidative stress marker.

Sections du résumé

BACKGROUND BACKGROUND
DNA is an important target for oxidative attack and its modification may increase the risk of mutagenesis. The aim of this study was to evaluate and compare salivary levels of the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in patients with oral cancer (OC) compared to the control group by a comprehensive search of the available literature.
METHODS METHODS
The present systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and was registered in Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/X3YMR. Four electronic databases were used to identify studies for this systematic review: PubMed, Scopus, ScienceDirect, and Web of Science from January 15, 2005, to April 15, 2021. The Joanna Briggs Institute (JBI) tool was used to assess article quality.
RESULTS RESULTS
Of the 166 articles identified, 130 articles were excluded on the basis of title and abstract screening (duplicates, reviews, etc.). Thirty-six articles were evaluated at full text and 7 articles met the inclusion criteria. Of these, only 5 studies had compatible data for quantitative analysis. An increase in salivary 8-OHdG levels was found in patients with OC compared to healthy subjects, but without statistical significance. 8-OHdG: SMD = 2,72 (95%CI= -0.25-5.70); *p = 0.07.
CONCLUSIONS CONCLUSIONS
This systematic review and meta-analysis suggests a clear trend of increased 8-OHdG levels in saliva of OC patients compared to the control group. However, further studies are required to clarify and understand the altered levels of this oxidative stress marker.

Identifiants

DOI: 10.1186/s12885-024-12746-0 PMID: 39107689
pubmed: 39107689
doi: 10.1186/s12885-024-12746-0
pii: 10.1186/s12885-024-12746-0
doi:

Substances chimiques

8-Hydroxy-2'-Deoxyguanosine 88847-89-6
Biomarkers, Tumor 0

Types de publication

Journal Article Systematic Review Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

960

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Mario Alberto Alarcón-Sánchez (MA)

Biomedical Science, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, 39090, Mexico. marioaasanchez@hotmail.com.
ORCID: 0000-0001-6727-7969

Lilibeth-Stephania Escoto-Vasquez (LS)

Department of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City, 04510, Mexico.
ORCID: 0000-0003-1608-8732

Artak Heboyan (A)

Department of Research Analytics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, 600 077, India. heboyan.artak@gmail.com.
Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Str. Koryun 2, Yerevan, 0025, Armenia. heboyan.artak@gmail.com.
Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, North Karegar St, Tehran, Iran. heboyan.artak@gmail.com.
ORCID: 0000-0001-8329-3205

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Salivary 8-hydroxy-2'-deoxyguanosine levels in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléoside purique › Désoxyguanosine › 8-Hydroxy-2'-désoxyguanosine › Salivary 8-hydroxy-2'-deoxyguanosine levels in...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Tumeurs de la bouche › Salivary 8-hydroxy-2'-deoxyguanosine levels in...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Salive › Salivary 8-hydroxy-2'-deoxyguanosine levels in...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Salivary 8-hydroxy-2'-deoxyguanosine levels in...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Salivary 8-hydroxy-2'-deoxyguanosine levels in...