Interpreting and managing preservation fluids positive for Gram-negative bacteria.
Journal
Current opinion in infectious diseases
ISSN: 1473-6527
Titre abrégé: Curr Opin Infect Dis
Pays: United States
ID NLM: 8809878
Informations de publication
Date de publication:
06 Aug 2024
06 Aug 2024
Historique:
medline:
7
8
2024
pubmed:
7
8
2024
entrez:
7
8
2024
Statut:
aheadofprint
Résumé
Culturing preservation fluids of solid organs before transplantation is not a standardized procedure. In this review, we aim to describe the state-of-the-art of literature evidence in this debated setting with a special focus on Gram-negative bacteria (GNB). Contamination of preservation fluids is frequent, but preservation fluids related infections are rare and most commonly caused by high-risk pathogens, including GNB. GNB preservation fluids related infections are characterized by high morbidity and mortality. Recent studies showed improved outcomes in solid organ transplant recipients receiving antibiotic therapy tailored according to preservation fluids cultures especially when multidrug-resistant GNB are found. A robust procurement network is needed to alert recipients' centers in cases of positivity and the support of transplant infectious diseases specialists is essential to choose the best therapy. Culturing preservation fluids is a further step into preventing donor-derived infections. Interpreting and managing GNB positivity require a multidisciplinary team with specific skills. Standardized randomized trials are needed for insight into the real utility of preservation fluids cultures, the role of preservation fluids positivity, and the impact of antimicrobial therapy.
Identifiants
pubmed: 39109933
doi: 10.1097/QCO.0000000000001058
pii: 00001432-990000000-00177
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Références
Fishman JA. Infection in organ transplantation. Am J Transplant 2017; 17:856–879.
Peghin M, Grossi PA. Donor-derived infections in solid organ transplant recipients. Curr Opin Organ Transplant 2023; 28:384–390.
Malinis M, Boucher HW, Practice ASTIDCo. Screening of donor and candidate prior to solid organ transplantation: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant 2019; 33:e13548.
Len O, Garzoni C, Lumbreras C, et al. Recommendations for screening of donor and recipient prior to solid organ transplantation and to minimize transmission of donor-derived infections. Clin Microbiol Infect 2014; 20: (Suppl 7): 10–18.
Fischer SA, Avery RK. Practice ASTIDCo Screening of donor and recipient prior to solid organ transplantation. Am J Transplant 2009; 9 Suppl 4: (Suppl 4): S7–S18.
Manuel O, van den Bogaart L, Mueller NJ, Neofytos D. Which trial do we need? Culture of preservation fluid in abdominal organ transplant recipients. Clin Microbiol Infect 2023; 29:832–834.
Lombardi A, Renisi G, Dondossola D, et al. Perfusion fluid-related infections in liver transplant recipients: a 5-year, single-center, retrospective study. Transpl Infect Dis 2023; 25:e14130.
Arena F, Giani T, Pollini S, et al. Molecular antibiogram in diagnostic clinical microbiology: advantages and challenges. Future Microbiol 2017; 12:361–364.
Mularoni A, Martucci G, Douradinha B, et al. Epidemiology and successful containment of a carbapenem-resistant Enterobacteriaceae outbreak in a Southern Italian Transplant Institute. Transpl Infect Dis 2019; 21:e13119.
Mularoni A, Cona A, Campanella M, et al. Donor-derived carbapenem-resistant gram-negative bacterial infections in solid organ transplant recipients: active surveillance enhances recipient safety. Am J Transplant 2024; 24:1046–1056.
Oriol I, Sabe N, Camara J, et al. The impact of culturing the organ preservation fluid on solid organ transplantation: a prospective multicenter cohort study. Open Forum Infect Dis 2019; 6:ofz180.
Yansouni CP, Dendukuri N, Liu G, et al. Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients. Infect Control Hosp Epidemiol 2012; 33:672–680.
Rinaldi M, Bonazzetti C, Gatti M, et al. The impact of preservation fluid culture on graft site arteritis: a systematic review and meta-analysis. Transpl Infect Dis 2022; 24:e13979.
Corbel A, Ladriere M, Le Berre N, et al. Microbiological epidemiology of preservation fluids in transplanted kidney: a nationwide retrospective observational study. Clin Microbiol Infect 2020; 26:475–484.
Tran-Dinh A, Tir I, Tanaka S, et al. Impact of culture-positive preservation fluid on early morbidity and mortality after lung transplantation. Transpl Int 2023; 36:10826.
Janny S, Bert F, Dondero F, et al. Microbiological findings of culture-positive preservation fluid in liver transplantation. Transpl Infect Dis 2011; 13:9–14.
Zhang F, Zhong J, Ding H, Liao G. Effects of preservative fluid associated possible donor-derived carbapenem-resistant Klebsiella Pneumoniae infection on kidney transplantation recipients. BMC Nephrol 2022; 23:101.
Oriol I, Llado L, Vila M, et al. The etiology, incidence, and impact of preservation fluid contamination during liver transplantation. PLoS One 2016; 11:e0160701.
Ruiz P, Gastaca M, Gonzalez J, et al. Incidence and clinical relevance of bacterial contamination in preservation solution for liver transplantation. Transplant Proc 2009; 41:2169–2171.
Grat M, Ligocka J, Lewandowski Z, et al. Incidence, pattern and clinical relevance of microbial contamination of preservation fluid in liver transplantation. Ann Transplant 2012; 17:20–28.
Zhang F, Wang W, Zhong J, et al. Effect of preservation fluid contamination and associated possible donor-derived infections on early postoperative prognosis in kidney transplant recipients. BMC Microbiol 2024; 24:189.
Lombardi A, Dondossola D, Renisi G, et al. Re: ’Which trial do we need? Culture of preservation fluid in abdominal-organ transplant recipients’ by Manuel et al. Clin Microbiol Infect 2023; 29:1202–1203.
Sui M, Zheng N, Xu D, et al. Colistin sulfate for decontamination of preservation fluid in kidney transplantation to decrease the incidence of donor-derived infections caused by multidrug-resistant Gram-negative bacteria. Transpl Infect Dis 2022; 24:e13820.
Li J, Su X, Li J, et al. The association of organ preservation fluid pathogens with early infection-related events after kidney transplantation. Diagnostics (Basel) 2022; 12:2248.
Oriol I, Sabe N, Tebe C, et al. Clinical impact of culture-positive preservation fluid on solid organ transplantation: a systematic review and meta-analysis. Transplant Rev (Orlando) 2018; 32:85–91.
Le Berre N, Ladriere M, Corbel A, et al. Antibiotic therapy in case of positive cultures of kidney transplant preservation fluid: a nationwide survey of prescribing practices. Eur J Clin Microbiol Infect Dis 2020; 39:915–921.
Reticker A, Lichvar A, Walsh M, et al. The significance and impact of screening preservation fluid cultures in renal transplant recipients. Prog Transplant 2021; 31:40–46.
Cai YS, Xiao H, Zhang S, et al. Carbapenem-resistant Klebsiella pneumoniae infection causing rupture of graft artery in solid organ recipients: case report and review of literature. Medicine (Baltimore) 2019; 98:e17878.
Giani T, Conte V, Mandala S, et al. Cross-infection of solid organ transplant recipients by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase, likely derived from a multiorgan donor. J Clin Microbiol 2014; 52:2702–2705.
Graziano E, Peghin M, Grossi PA. Perioperative antibiotic stewardship in the organ transplant setting. Transpl Infect Dis 2022; 24:e13895.
Ranghino A, Diena D, Simonato F, et al. Clinical impact of bacterial contamination of perfusion fluid in kidney transplantation. Springerplus 2016; 5:7.
Guo M, Pan C, Zhao Y, et al. Development of a risk prediction model for infection after kidney transplantation transmitted from bacterial contaminated preservation solution. Infect Drug Resist 2024; 17:977–988.
Boutin CA, Pouch SM, Ison MG. Utility of deceased donor cultures in solid organ transplantation in preventing donor-derived bacterial and fungal infectious diseases transmission. Transpl Infect Dis 2023; 25:e14032.
Goenaga-Mafud LC, Gamez YM, Campos CP, et al. Kidney decontamination during perfusion for transplantation procedure: in vitro and ex vivo viability analysis. J Biophotonics 2022; 15:e202100319.