Zinc transporter 1 functions in copper uptake and cuproptosis.
Cu transporter
Wilson's disease
ZnT1
cryo-EM
cuproptosis
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
received:
05
12
2023
revised:
05
05
2024
accepted:
09
07
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
aheadofprint
Résumé
Copper (Cu) is a co-factor for several essential metabolic enzymes. Disruption of Cu homeostasis results in genetic diseases such as Wilson's disease. Here, we show that the zinc transporter 1 (ZnT1), known to export zinc (Zn) out of the cell, also mediates Cu
Identifiants
pubmed: 39111308
pii: S1550-4131(24)00279-1
doi: 10.1016/j.cmet.2024.07.009
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.