Sphingosine-1 phosphate receptor 1 (S1PR1) expression maintains stemness of acute myeloid leukemia stem cells.

Acute myeloid leukemia (AML) arises from leukemia stem cells (LSCs) and is maintained by cells which have acquired features of stemness. We compared transcription profiles of AML cells with/without stem cell features defined as in vitro clonogenicity and serial engraftment in immune-deficient mice xenograft model. We used multi-parameter flow cytometry (MPFC) to separate CD34

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Déclaration de conflit d'intérêts

Declaration of Competing Interest ☐ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☒ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Robert Peter Gale reports a relationship with Antengene Biotech Limited Liability Company that includes: consulting or advisory. Robert Peter Gale reports a relationship with FFF Enterprises Inc that includes: board membership. Robert Peter Gale reports a relationship with Janssen Pharma and Hengrui Pharma that includes: speaking and lecture fees. Robert Peter Gale reports a relationship with Russian Foundation for Cancer Research Support and Scientific Advisory Board, StemRad Ltd that includes: board membership. Xiaojun Huang has patent #202310435300.1 pending to Peking University People’s Hospital. Xiaojun Huang has patent #202311626667.8 pending to Peking University People’s Hospital. No If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.