The hematopoietic niche and the autoreactive memory in autoimmune disorders.
Autoimmunity
B and T cell memory
Bone marrow niche
Hematopoiesis
Inflammation
Journal
Handbook of clinical neurology
ISSN: 0072-9752
Titre abrégé: Handb Clin Neurol
Pays: Netherlands
ID NLM: 0166161
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
ppublish
Résumé
Hematopoiesis is a complex process that takes place inside the bone marrow, where a specialized structure, the bone marrow niche, participates in the maintenance of hematopoietic stem cell functionality. Inflammatory conditions, such as autoimmune diseases, could alter this equilibrium leading to pathologic consequences. Immune cells, which also reside in the bone marrow, directly participate in sustaining the inflammatory state in autoimmune diseases. In particular, memory lymphocytes are key players in the long-term maintenance of the immune response against self-antigens, causing tissue damage and bone marrow alterations.
Identifiants
pubmed: 39111909
pii: B978-0-323-90242-7.00006-7
doi: 10.1016/B978-0-323-90242-7.00006-7
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-39Informations de copyright
Copyright © 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.