Ultra-high Versus Standard Resolution Photon-Counting Detector CT Angiography for Imaging of Femoral Stents in a Cadaveric Perfusion Model.

Image quality Peripheral arterial disease Peripheral arterial runoff Photon-counting CT Ultra-high resolution

Journal

Academic radiology
ISSN: 1878-4046
Titre abrégé: Acad Radiol
Pays: United States
ID NLM: 9440159

Informations de publication

Date de publication:
06 Aug 2024
Historique:
received: 19 06 2024
revised: 18 07 2024
accepted: 21 07 2024
medline: 8 8 2024
pubmed: 8 8 2024
entrez: 7 8 2024
Statut: aheadofprint

Résumé

The aim of this study was to investigate the imaging performance and quality differences of PCD-CT in standard resolution mode (SR) versus ultra-high resolution mode (UHR) in the lower extremity runoff of dose-matched CTAs in a human cadaveric model. Extracorporeal perfusion of the upper leg was established in one fresh-frozen human cadaver via inguinal and popliteal accesses using a peristaltic pump. Seven peripheral stents were deployed in the SFA. Photon-counting CTAs were performed under contrast perfusion in SR and UHR mode with dose-equivalent 120kVp acquisition protocols (low-/ medium-/ high-dose: CTDI Lumen visibility was equal for SR and UHR at the used dose levels. CNR increase by UHR was significant for (ultra-)sharp convolution kernels BV60 (3 mGy; UHR vs. SR, 19.9 ± 1.9 vs. 15.7 ± 1.6, p < 0.046) and BV76 (8.0 ± 0.6 vs. 5.4 ± 0.3, p < 0.001). The relative CNR increase was higher for low-dose than high-dose scans (BV76: 48% vs. 36% at high dose, p < 0.033). The CNR of the low-dose scan in UHR mode was comparable to the high-dose scan in SR mode when the ultra-sharp kernel was used (8.0 ± 0.6 vs. 9.1 ± 1.1, p > 0.760). Among UHR examinations, a significant increase in CNR could only be measured in BV76 (8.0 ± 0.6 (3 mGy) vs. 12.4 ± 0.9 (10 mGy), p < 0.001). Readers preferred subjective image quality of UHR for all kernels with BV76 being ranked highest. The CNR increase in UHR mode is highest when combining low radiation dose and ultra-sharp reconstructions. Meanwhile, the subjective image quality in UHR mode generally supersedes SR images, suggesting further dose reduction potential.

Sections du résumé

BACKGROUND AND AIMS OBJECTIVE
The aim of this study was to investigate the imaging performance and quality differences of PCD-CT in standard resolution mode (SR) versus ultra-high resolution mode (UHR) in the lower extremity runoff of dose-matched CTAs in a human cadaveric model.
METHODS METHODS
Extracorporeal perfusion of the upper leg was established in one fresh-frozen human cadaver via inguinal and popliteal accesses using a peristaltic pump. Seven peripheral stents were deployed in the SFA. Photon-counting CTAs were performed under contrast perfusion in SR and UHR mode with dose-equivalent 120kVp acquisition protocols (low-/ medium-/ high-dose: CTDI
RESULTS RESULTS
Lumen visibility was equal for SR and UHR at the used dose levels. CNR increase by UHR was significant for (ultra-)sharp convolution kernels BV60 (3 mGy; UHR vs. SR, 19.9 ± 1.9 vs. 15.7 ± 1.6, p < 0.046) and BV76 (8.0 ± 0.6 vs. 5.4 ± 0.3, p < 0.001). The relative CNR increase was higher for low-dose than high-dose scans (BV76: 48% vs. 36% at high dose, p < 0.033). The CNR of the low-dose scan in UHR mode was comparable to the high-dose scan in SR mode when the ultra-sharp kernel was used (8.0 ± 0.6 vs. 9.1 ± 1.1, p > 0.760). Among UHR examinations, a significant increase in CNR could only be measured in BV76 (8.0 ± 0.6 (3 mGy) vs. 12.4 ± 0.9 (10 mGy), p < 0.001). Readers preferred subjective image quality of UHR for all kernels with BV76 being ranked highest.
CONCLUSION CONCLUSIONS
The CNR increase in UHR mode is highest when combining low radiation dose and ultra-sharp reconstructions. Meanwhile, the subjective image quality in UHR mode generally supersedes SR images, suggesting further dose reduction potential.

Identifiants

DOI: 10.1016/j.acra.2024.07.038 PMID: 39112296
pubmed: 39112296
pii: S1076-6332(24)00474-4
doi: 10.1016/j.acra.2024.07.038
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest Two of the authors (J.P.G. and T.A.B.) receive speaker honoraria from Siemens Healthcare GmbH. The other authors declare no relationships with any companies, related to the matter of the article. One author (V.H.) receives a research grant from Abbott in the form of the provided stents.

Auteurs

Viktor Hartung (V)

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany (V.H., R.H., H.H., A.M.A., J.P.G., T.A.B., P.G.). Electronic address: hartung_v@ukw.de.

Robin Hendel (R)

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany (V.H., R.H., H.H., A.M.A., J.P.G., T.A.B., P.G.).

Henner Huflage (H)

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany (V.H., R.H., H.H., A.M.A., J.P.G., T.A.B., P.G.).

Anne Marie Augustin (AM)

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany (V.H., R.H., H.H., A.M.A., J.P.G., T.A.B., P.G.); Department of Interventional and Diagnostic Radiology, Klinikum Bayreuth, Bayreuth, Germany (A.M.A.).

Jan-Peter Grunz (JP)

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany (V.H., R.H., H.H., A.M.A., J.P.G., T.A.B., P.G.); Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA (J.P.G.).

Florian Kleefeldt (F)

Institute of Anatomy and Cell Biology, University Würzburg, Würzburg, Germany (F.K., S.E.).

Dominik Peter (D)

Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, Center of Operative Medicine, University Hospital Würzburg, Würzburg, Germany (D.P., S.L.).

Sven Lichthardt (S)

Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, Center of Operative Medicine, University Hospital Würzburg, Würzburg, Germany (D.P., S.L.).

Süleyman Ergün (S)

Institute of Anatomy and Cell Biology, University Würzburg, Würzburg, Germany (F.K., S.E.).

Thorsten Alexander Bley (TA)

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany (V.H., R.H., H.H., A.M.A., J.P.G., T.A.B., P.G.).

Philipp Gruschwitz (P)

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany (V.H., R.H., H.H., A.M.A., J.P.G., T.A.B., P.G.).

Classifications MeSH