Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy.
Bone tumor resection margins
Bone-invasive oral cancer
Laser-induced breakdown spectroscopy
Rapid bone analysis
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
08 Aug 2024
08 Aug 2024
Historique:
received:
02
06
2024
accepted:
29
07
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
epublish
Résumé
Inadequate resection margins of less than 5 mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS). LIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins < 1 mm were defined as very close, from 1-5 mm as close, and > 5 mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined. LIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis/fibrosis and lymphocyte/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (p < 0.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%. LIBS can reliably determine the boundary of bone-infiltrating tumors and might provide an orientation for determining a clear resection margin. LIBS could facilitate intraoperative decision-making and avoid inadequate resection margins in bone-invasive oral cancer.
Identifiants
pubmed: 39112646
doi: 10.1007/s00784-024-05862-5
pii: 10.1007/s00784-024-05862-5
doi:
Substances chimiques
Calcium
SY7Q814VUP
Potassium
RWP5GA015D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
474Subventions
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Organisme : Schäfersnolte-Gedächtnis-Stiftung Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
ID : Fonds 361717 MKG
Informations de copyright
© 2024. The Author(s).
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