Imaging findings of thoracic manifestations of Crohn's disease and ulcerative colitis.
Bronchial diseases
Inflammatory bowel diseases
Multidetector computed tomography
Pneumonia
Tracheal diseases
Journal
Insights into imaging
ISSN: 1869-4101
Titre abrégé: Insights Imaging
Pays: Germany
ID NLM: 101532453
Informations de publication
Date de publication:
07 Aug 2024
07 Aug 2024
Historique:
received:
30
01
2024
accepted:
16
06
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
epublish
Résumé
Thoracic manifestations of inflammatory bowel disease (IBD) are rare, occurring in less than 1% of patients. Unlike most other extra-intestinal manifestations, they predominate in patients with ulcerative colitis rather than in Crohn's disease. In most patients, thoracic involvement follows the onset of IBD by several years. However, thoracic involvement may also occur synchronously or even precede the onset of digestive symptoms. The thoracic manifestations of IBD include airway involvement and parenchymal lung abnormalities. Airways are the most frequent anatomical site for thoracic involvement in IBD. Airway manifestations usually develop several years after the onset of intestinal manifestations, preferentially when the latter are stable or in remission. Airway manifestations include bronchial wall thickening, bronchiectasis, small airway disease, and tracheal wall thickening. Parenchymal lung abnormalities are less prevalent in IBD and include organizing pneumonia, necrobiotic nodules, noncaseating granulomatous nodules, drug-induced pneumonia, and rarely interstitial lung diseases. The differential diagnosis between organizing pneumonia, necrobiotic nodules, and noncaseating granulomatous nodules is difficult and usually requires histopathological analysis for a definite diagnosis. Radiologists play a key role in the detection of thoracic manifestations of Crohn's disease and ulcerative colitis and, therefore, need to be familiar with their imaging findings. This article aims to offer an overview of the imaging findings of thoracic manifestations in patients with Crohn's disease or ulcerative colitis. CRITICAL RELEVANCE STATEMENT: Thoracic manifestations of Crohn's disease and ulcerative colitis include tracheal involvement, bronchiectasis, small airway disease, and parenchymal lung abnormalities such as organizing pneumonia and necrobiotic nodules. These rare manifestations (< 1% of patients) more often affect patients with ulcerative colitis. KEY POINTS: Thoracic manifestations of inflammatory bowel disease are rare, occurring in less than 1% of patients. Thoracic manifestations are more frequent in patients with ulcerative colitis than Crohn's disease. Bronchial disease is the most frequent thoracic manifestation of Crohn's disease and ulcerative colitis.
Identifiants
pubmed: 39112694
doi: 10.1186/s13244-024-01742-4
pii: 10.1186/s13244-024-01742-4
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
197Informations de copyright
© 2024. The Author(s).
Références
Djelouah M, Marical V, Kanagaratnam L et al (2021) Diagnosis of postoperative recurrence of Crohn disease with MR-enterography: value of diffusion-weighted imaging. Diagn Interv Imaging 102:743–751
pubmed: 34154981
doi: 10.1016/j.diii.2021.06.002
Hemmer A, Forest K, Rath J, Bowman J (2023) Inflammatory bowel disease: a concise review. S D Med 76:416–423
pubmed: 37738497
Olpin JD, Sjoberg BP, Stilwill SE et al (2017) Beyond the bowel: extraintestinal manifestations of inflammatory bowel disease. Radiographics 37:1135–1160
pubmed: 28548906
doi: 10.1148/rg.2017160121
Rogler G, Singh A, Kavanaugh A, Rubin DT (2021) Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management. Gastroenterology 161:1118–1132
pubmed: 34358489
doi: 10.1053/j.gastro.2021.07.042
Ji X-Q (2014) Pulmonary manifestations of inflammatory bowel disease. World J Gastroenterol 20:13501
pubmed: 25309080
pmcid: 4188901
doi: 10.3748/wjg.v20.i37.13501
Turner-Warwick M (1968) Fibrosing alveolitis and chronic liver disease. Q J Med 37:133–149
pubmed: 4872529
Kraft SC, Earle RH, Roesler M, Esterly JR (1976) Unexplained bronchopulmonary disease with inflammatory bowel disease. Arch Intern Med 136:454–459
pubmed: 1267553
doi: 10.1001/archinte.1976.03630040056012
Desai D, Patil S, Udwadia Z et al (2011) Pulmonary manifestations in inflammatory bowel disease: a prospective study. Indian J Gastroenterol 30:225–228
pubmed: 21935713
doi: 10.1007/s12664-011-0129-1
Hoffmann RM, Kruis W (2004) Rare extraintestinal manifestations of inflammatory bowel disease. Inflamm Bowel Dis 10:140–147
pubmed: 15168815
doi: 10.1097/00054725-200403000-00013
Kelly MG, Frizelle FA, Thornley PT et al (2006) Inflammatory bowel disease and the lung: is there a link between surgery and bronchiectasis? Int J Colorectal Dis 21:754–757
pubmed: 16625374
doi: 10.1007/s00384-006-0094-9
Songür N, Songür Y, Tüzün M et al (2003) Pulmonary Function Tests and High-Resolution CT in the Detection of Pulmonary Involvement in Inflammatory Bowel Disease. J Clin Gastroenterol 37:292–298
pubmed: 14506385
doi: 10.1097/00004836-200310000-00006
Sarıoğlu N, Türkel N, Şakar A et al (2006) Lung involvement in inflammatory bowel diseases. Ann Saudi Med 26:407–408
pubmed: 17019097
pmcid: 6074116
doi: 10.5144/0256-4947.2006.407
Tzanakis N, Samiou M, Bouros D et al (1998) Small Airways Function in Patients with Inflammatory Bowel Disease. Am J Respir Crit Care Med 157:382–386
pubmed: 9476847
doi: 10.1164/ajrccm.157.2.97-04075
Black H, Mendoza M, Murin S (2007) Thoracic Manifestations of Inflammatory Bowel Disease. Chest 131:524–532
pubmed: 17296657
doi: 10.1378/chest.06-1074
Basseri B, Enayati P, Marchevsky A, Papadakis KA (2010) Pulmonary manifestations of inflammatory bowel disease: Case presentations and review. J Crohns Colitis 4:390–397
pubmed: 21122534
doi: 10.1016/j.crohns.2010.03.008
Camus P, Piard F, Ashcroft T et al (1993) The lung in inflammatory bowel disease. Medicine (Baltimore) 72:151–183
pubmed: 8502168
doi: 10.1097/00005792-199372030-00003
Mestecky J (1987) The common mucosal immune system and current strategies for induction of immune responses in external secretions. J Clin Immunol 7:265–276
pubmed: 3301884
doi: 10.1007/BF00915547
Williams H, Walker D, Orchard TR (2008) Extraintestinal manifestations of inflammatory bowel disease. Curr Gastroenterol Rep 10:597–605
pubmed: 19006617
doi: 10.1007/s11894-008-0108-6
Vutcovici M, Brassard P, Bitton A (2016) Inflammatory bowel disease and airway diseases. World J Gastroenterol 22:7735–7741
pubmed: 27678355
pmcid: 5016372
doi: 10.3748/wjg.v22.i34.7735
Papanikolaou I, Kagouridis K, Papiris SA (2014) Patterns of airway involvement in inflammatory bowel diseases. World J Gastrointest Pathophysiol 5:560–569
pubmed: 25400999
pmcid: 4231520
doi: 10.4291/wjgp.v5.i4.560
Betancourt SL, Palacio D, Jimenez CA et al (2011) Thoracic Manifestations of Inflammatory Bowel Disease. AJR. Am J Roentgenol 197:W452–W456
doi: 10.2214/AJR.10.5353
Yamamoto AK, Babar JL (2012) Case 184: Ulcerative Tracheobronchitis. Radiology 264:609–613
pubmed: 22821697
doi: 10.1148/radiol.12110413
Vasishta S, Wood JB, McGinty F (1994) Ulcerative tracheobronchitis years after colectomy for ulcerative colitis. Chest 106:1279–1281
pubmed: 7924516
doi: 10.1378/chest.106.4.1279
KuzÂniar T, Sleiman C, Pariente R et al (2000) Severe tracheobronchial stenosis in a patient with Crohn’s disease. Eur Respir J 15:209–212
Shad JA, Sharieff GQ (2001) Tracheobronchitis as an initial presentation of ulcerative colitis. J Clin Gastroenterol 33:161–163
pubmed: 11468448
doi: 10.1097/00004836-200108000-00016
Bayraktaroglu S, Basoglu O, Ceylan N et al (2010) A rare extraintestinal manifestation of ulcerative colitis: tracheobronchitis associated with ulcerative colitis. J Crohns Colitis 4:679–682
pubmed: 21122581
doi: 10.1016/j.crohns.2010.06.003
Lu DG, Ji XQ, Liu X et al (2014) Pulmonary manifestations of Crohn’s disease. World J Gastroenterol 20:133–141
pubmed: 24415866
pmcid: 3886002
doi: 10.3748/wjg.v20.i1.133
Pemmasani G, Loftus EV, Tremaine WJ (2022) Prevalence of Pulmonary Diseases in Association with Inflammatory Bowel Disease. Dig Dis Sci 67:5187–5194
pubmed: 35142913
doi: 10.1007/s10620-022-07385-z
Lucidarme O, Grenier P, Coche E et al (1996) Bronchiectasis: comparative assessment with thin-section CT and helical CT. Radiology 200:673–679
pubmed: 8756913
doi: 10.1148/radiology.200.3.8756913
Cozzi D, Moroni C, Addeo G et al (2018) Radiological Patterns of Lung Involvement in Inflammatory Bowel Disease. Gastroenterol Res Pract 2018:1–10
doi: 10.1155/2018/5697846
Gupta SJ, Gupta VL, Kothari HG et al (2020) Assessment of Occult Pulmonary Involvement in Ulcerative Colitis. Inflamm Intest Dis 5:144–150
pubmed: 32999887
pmcid: 7506263
doi: 10.1159/000508772
Bouchentouf (2012) Respiratory manifestations of inflammatory bowel disease. J Func Vent Pulm 3:1–41
Casey MB, Tazelaar HD, Myers JL et al (2003) Noninfectious lung pathology in patients with Crohn’s disease. Am J Surg Pathol 27:213–219
pubmed: 12548168
doi: 10.1097/00000478-200302000-00010
Bommart S, Charriot J, Nagot N et al (2021) Differentiating between active and latent tuberculosis with chest computed tomography. Diagn Interv Imaging 102:605–610
pubmed: 34183300
doi: 10.1016/j.diii.2021.05.011
Papiris SA, Malagari K, Manali ED et al (2013) Bronchiolitis: adopting a unifying definition and a comprehensive etiological classification. Expert Rev Respir Med 7:289–306
pubmed: 23734650
doi: 10.1586/ers.13.21
Majewski S, Piotrowski W (2015) Pulmonary manifestations of inflammatory bowel disease. Arch Med Sci 11:1179–1188
pubmed: 26788078
pmcid: 4697051
doi: 10.5114/aoms.2015.56343
Storch I, Sachar D, Katz S (2003) Pulmonary Manifestations of Inflammatory Bowel Disease. Inflamm Bowel Dis 9:104–115
pubmed: 12769444
doi: 10.1097/00054725-200303000-00004
Schwaiblmair M, Behr W, Haeckel T et al (2012) Drug Induced Interstitial Lung Disease. Open Respir Med J 6:63–74
pubmed: 22896776
pmcid: 3415629
doi: 10.2174/1874306401206010063
Petitpierre N, Beigelman C, Letovanec I, Lazor R (2016) Cryptogenic organizing pneumonia. Rev Mal Respir 33:703–717
pubmed: 26857200
doi: 10.1016/j.rmr.2015.08.004
Akira M, Yamamoto S, Sakatani M (1998) Bronchiolitis obliterans organizing pneumonia manifesting as multiple large nodules or masses. AJR Am J Roentgenol 170:291–295
pubmed: 9456931
doi: 10.2214/ajr.170.2.9456931
Marchiori E, Zanetti G, Hochhegger B et al (2012) Reversed halo sign on computed tomography: state-of-the-art review. Lung 190:389–394
pubmed: 22573292
doi: 10.1007/s00408-012-9392-x
Baha A, Yildirim F, Kokturk N et al (2016)
doi: 10.1111/crj.12280
Faller M, Gasser B, Massard G et al (2000) Pulmonary migratory infiltrates and pachypleuritis in a patient with Crohn’s disease. Respiration 67:459–463
pubmed: 10940806
doi: 10.1159/000029550
El-Kersh K, Fraig M, Cavallazzi R et al (2014) Pulmonary Necrobiotic Nodules in Crohn’s Disease: A Rare Extra-intestinal Manifestation. Respir Care 59:e190–e192
pubmed: 25233391
doi: 10.4187/respcare.03176
Barbosa M, Gondim F, Vosqui F et al (2012) P-15 Pulmonary Necrobiotic Nodules in a Patient With UC and Primary Sclerosing Cholangitis: a Rare Extraintestinal Manifestation of IBD: Case Report:. Inflamm Bowel Dis 18:S19
doi: 10.1097/00054725-201212001-00048
Mukherjee S, Harne P, Mirchia K et al (2020) Necrobiotic Pulmonary Nodules in Ulcerative Colitis: Not Just a “Crohnic” Phenomenon. ACG Case Rep J 7:e00438
pubmed: 32903944
pmcid: 7447367
doi: 10.14309/crj.0000000000000438
Nomoto H, Hayashi Y, Shinozaki S et al (2014) Ulcerative colitis-associated pulmonary nodules with cavity formation successfully treated with mesalazine and granulocyte-monocyte apheresis. Clin J Gastroenterol 7:476–480
pubmed: 25491905
doi: 10.1007/s12328-014-0530-2
Freeman HJ, Davis JE, Prest ME, Lawson EJ (2004) Granulomatous bronchiolitis with necrobiotic pulmonary nodules in Crohn’s disease. Can J Gastroenterol 18:687–690
pubmed: 15565210
doi: 10.1155/2004/729689
Roblin E, Pecciarini N, Yantren H et al (2010) Granulomatous pulmonary involvement preceding diagnosis of Crohn disease: a pediatric case report. Arch Pedi 17:1308–1312
doi: 10.1016/j.arcped.2010.06.006
Puntis JW, Tarlow MJ, Raafat F, Booth IW (1990) Crohn’s disease of the lung. Arch Dis Child 65:1270–1271
pubmed: 2248544
pmcid: 1792605
doi: 10.1136/adc.65.11.1270
Warwick G, Leecy T, Silverstone E et al (2009) Pulmonary necrobiotic nodules: a rare extraintestinal manifestation of Crohn’s disease. Eur Respir Rev 18:47–50
pubmed: 20956123
doi: 10.1183/09059180.00011114
Myer AS, Shah K, Patel KM (2020) An Infrequent Extraintestinal Manifestation of Ulcerative Colitis: Pulmonary Necrobiotic Nodules. Cureus 16:e9774
Eliadou E, Moleiro J, Ribaldone DG et al (2020) Interstitial and Granulomatous Lung Disease in Inflammatory Bowel Disease Patients. J Crohns Colitis 14:480–489
pubmed: 31602473
doi: 10.1093/ecco-jcc/jjz165
Assioura A, Gkrepi G, Exarchos K et al (2022) Recurrent bilateral lung infiltrates in a patient with ulcerative colitis. Breathe 18:220210
pubmed: 36865931
doi: 10.1183/20734735.0210-2022
Ishii H, Watanabe K, Kushima H et al (2018) Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan. Respir Med 141:190–197
pubmed: 30053966
doi: 10.1016/j.rmed.2018.06.022
Xu L, Xiao W, Ma D et al (2014) Ulcerative colitis combined with acute interstitial lung disease and airway disease: a case report and literature review. Exp Ther Med 8:1229–1236
pubmed: 25187830
pmcid: 4151782
doi: 10.3892/etm.2014.1895
Moon E, Gillespie CT, Vachani A (2009) Pulmonary complications of inflammatory bowel disease: focus on management issues. Tech Gastrointest Endos 11:127–139
doi: 10.1016/j.tgie.2009.07.002
Li L, Liu P, Niu X, He C (2022) Interstitial Lung Disease as an Extraintestinal Manifestation of Crohn’s Disease in the Time of COVID-19: A Rare Case Report and Review of the Literature. J Inflamm Res 15:5733–5737
pubmed: 36238767
pmcid: 9553307
doi: 10.2147/JIR.S380879
Sheehan RE, English J, Wittmann R, Müller NL (2003) Levitating consolidation in eosinophilic lung disease. J Thorac Imaging 18:45–47
pubmed: 12544747
doi: 10.1097/00005382-200301000-00007
Kantsø B, Simonsen J, Hoffmann S et al (2015) Inflammatory Bowel Disease Patients Are at Increased Risk of Invasive Pneumococcal Disease: A Nationwide Danish Cohort Study 1977-2013. Am J Gastroenterol 110:1582–1587
pubmed: 26346865
doi: 10.1038/ajg.2015.284
Kucharzik T, Ellul P, Greuter T et al (2021) ECCO Guidelines on the Prevention, Diagnosis, and Management of Infections in Inflammatory Bowel Disease J Crohns Colitis 15:879–913
pubmed: 33730753
doi: 10.1093/ecco-jcc/jjab052