Effects of increasing tidal volume and end-expiratory lung volume on induced bronchoconstriction in healthy humans.
Humans
Bronchoconstriction
/ drug effects
Tidal Volume
/ physiology
Male
Female
Adult
Young Adult
Methacholine Chloride
/ administration & dosage
Bronchoconstrictor Agents
/ administration & dosage
Bronchial Provocation Tests
/ methods
Functional Residual Capacity
/ physiology
Healthy Volunteers
Airway Resistance
/ drug effects
Lung
/ drug effects
Forced Expiratory Volume
/ physiology
Airway caliber
Lung volume
Methacholine
Oscillometry
Tidal breathing
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
07 Aug 2024
07 Aug 2024
Historique:
received:
23
04
2024
accepted:
07
07
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
epublish
Résumé
Increasing functional residual capacity (FRC) or tidal volume (V Nineteen healthy volunteers were challenged with a single-dose of MCh and forced oscillation was used to measure inspiratory resistance at 5 and 19 Hz (R Tripling V These data show that increasing FRC and V
Sections du résumé
BACKGROUND
BACKGROUND
Increasing functional residual capacity (FRC) or tidal volume (V
METHODS
METHODS
Nineteen healthy volunteers were challenged with a single-dose of MCh and forced oscillation was used to measure inspiratory resistance at 5 and 19 Hz (R
RESULTS
RESULTS
Tripling V
CONCLUSIONS
CONCLUSIONS
These data show that increasing FRC and V
Identifiants
pubmed: 39113017
doi: 10.1186/s12931-024-02909-9
pii: 10.1186/s12931-024-02909-9
doi:
Substances chimiques
Methacholine Chloride
0W5ETF9M2K
Bronchoconstrictor Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
298Informations de copyright
© 2024. The Author(s).
Références
Briscoe WA. The relationship between airway resistance, airway conductance and lung volume in subjects of different age and body size. J Clin Invest. 1958;37:1279–85. https://doi.org/10.1172/JCI103715 .
doi: 10.1172/JCI103715
pubmed: 13575526
pmcid: 1062796
Brusasco V, Warner DO, Beck KC, Rodarte JR, Rehder K. Partitioning of pulmonary resistance in dogs: effect of tidal volume and frequency. J Appl Physiol. 1989;66:1190–6. https://doi.org/10.1152/jappl.1989.66.3.1190 .
doi: 10.1152/jappl.1989.66.3.1190
pubmed: 2708244
Ding DJ, Martin JG, Macklem PT. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol. 1987;62:1324–30.
doi: 10.1152/jappl.1987.62.3.1324
pubmed: 3553143
Salerno FG, Pellegrino R, Torchio G, Spanevello A, Brusasco V, Crimi E. Attenuation of induced bronchoconstriction in healthy subjects: effects of breathing depth. J Appl Physiol. 2005;98:817–21. https://doi.org/10.1152/japplphysiol.00763.2004 .
doi: 10.1152/japplphysiol.00763.2004
pubmed: 15475599
Oliver MN, Fabry B, Marinkovic A, Mijailovich SM, Butler JP. Fredberg JJ Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason? Am J Respir Cell Mol Biol. 2007;37:264–72.
doi: 10.1165/rcmb.2006-0418OC
pubmed: 17463392
pmcid: 1994228
Gunst SJ, Meiss RA, Wu MF, Rowe M. Mechanisms for the mechanical plasticity of tracheal smooth muscle. Am J Physiol. 1995;268:C1267–76.
doi: 10.1152/ajpcell.1995.268.5.C1267
pubmed: 7762621
LaPrad AS, Szabo TL, Suki B, Lutchen KR. Tidal stretches do not modulate responsiveness of intact airways in vitro. J Appl Physiol. 2010;109:295–304. https://doi.org/10.1152/japplphysiol.00107.2010 . Epub 2010 Apr 29. PMID: 20431023; PMCID: PMC2928594.
doi: 10.1152/japplphysiol.00107.2010
pubmed: 20431023
pmcid: 2928594
Shen X, Gunst SJ, Tepper RS. Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits. J Appl Physiol. 1997;83:1202–8. https://doi.org/10.1152/jappl.1997.83.4.1202 .
doi: 10.1152/jappl.1997.83.4.1202
pubmed: 9338429
Cairncross A, Noble PB, McFawn PK. Hyperinflation of bronchi in vitro impairs bronchodilation to simulated breathing and increases sensitivity to contractile activation. Respirology. 2018;23:750–5. https://doi.org/10.1111/resp.13271 . Epub 2018 Feb 20 PMID: 29462842.
doi: 10.1111/resp.13271
pubmed: 29462842
Miller M, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J. Standardization of spirometry. Eur Respir J. 2005;26:319–38.
doi: 10.1183/09031936.05.00034805
pubmed: 16055882
Dellacà RL, Gobbi A, Pastena M, Pedotti A, Celli B. Home monitoring of within-breath respiratory mechanics by a simple and automatic forced oscillation technique device. Physiol Meas. 2010;31(4):N11.
doi: 10.1088/0967-3334/31/4/N01
pubmed: 20182000
Gobbi A, Milesi I, Govoni L, Pedotti A, Dellaca RL. A new telemedicine system for the home monitoring of lung function in patients with obstructive respiratory diseases. eHealth, Telemedicine, and Social Medicine, 2009. eTELEMED'09. International Conference (pp. 117-122). IEEE.
Kaczka DW, Barnas GM, Suki B, Lutchen KR. Assessment of time-domain analyses for estimation of low-frequency respiratory mechanical properties and impedance spectra. Ann Biomed Eng. 1995;23:135–51.
doi: 10.1007/BF02368321
pubmed: 7605051
Kaczka DW, Ingenito EP, Lutchen KR. Technique to determine inspiratory impedance during mechanical ventilation: implication for flow limited patients. Ann Biomed Eng. 1999;27:340–55.
doi: 10.1114/1.146
pubmed: 10374726
Marchal F, Schweitzer C, Demoulin B, Chone C, Peslin R. Filtering artefacts in measurements of forced oscillation respiratory impedance in young children. Physiol Meas. 2004;25:1153–66.
doi: 10.1088/0967-3334/25/5/006
pubmed: 15535181
Barnas GM, Heglund NC, Yager D, Yoshino K, Loring SH, Mead J. Impedance of the chest wall during sustained respiratory muscle contraction. J Appl Physiol. 1989;66:360–9. https://doi.org/10.1152/jappl.1989.66.1.360 . PMID: 2917942.
doi: 10.1152/jappl.1989.66.1.360
pubmed: 2917942
Newhouse MT, Becklake MR, Macklem PT, McGregor M. Effect of alterations in end-tidal CO
doi: 10.1152/jappl.1964.19.4.745
pubmed: 14195587
van den Elshout FJ, van Herwaarden CL, Folgering HT. Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects. Thorax. 1991;46:28–32. https://doi.org/10.1136/thx.46.1.28 . PMID: 1908137; PMCID: PMC1020910.
doi: 10.1136/thx.46.1.28
pubmed: 1908137
pmcid: 1020910
Hughes JMB, Hoppin FG, Mead J. Effect of lung inflation on bronchial length and diameter in excised lungs. J Appl Physiol. 1972;32:25–35.
doi: 10.1152/jappl.1972.32.1.25
pubmed: 5007013
Wilson AG, Massarella GR, Pride NB. Elastic properties of airways in human lungs post mortem. Am Rev Respir Dis. 1974;110:716–29.
pubmed: 4429267
Bossé Y, Sobieszek A, Paré PD, Seow CY. Length adaptation of airway smooth muscle. Proc Am Thorac Soc. 2008;5:62–7.
doi: 10.1513/pats.200705-056VS
pubmed: 18094086
Bossé Y. The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity. J Eng Sci Med Diagn Ther. 2019;2:0108021–01080221. https://doi.org/10.1115/1.4042309 .
doi: 10.1115/1.4042309
pubmed: 32328568
pmcid: 7164505
Ansell TK, McFawn PK, McLaughlin RA, Sampson DD, Eastwood PR, Hillman DR, Mitchell HW, Noble PB. Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure? J Appl Physiol. 2015;118:533–43. https://doi.org/10.1152/japplphysiol.00724.2014 .
doi: 10.1152/japplphysiol.00724.2014
pubmed: 25729015
Torchio R, Gobbi A, Gulotta C, Antonelli A, Dellacà R, Pellegrino GM, Pellegrino R, Brusasco V. Role of hyperpnea in the relaxant effect of inspired CO
doi: 10.1152/japplphysiol.00763.2021
pubmed: 35358399
Oliver M, Kováts T, Mijailovich SM, Butler JP, Fredberg JJ, Lenormand G. Remodeling of integrated contractile tissues and its dependence on strain-rate amplitude. Phys Rev Lett. 2010;105(15):158102. https://doi.org/10.1103/PhysRevLett.105.158102 . Epub 2010 Oct 4.
doi: 10.1103/PhysRevLett.105.158102
pubmed: 21230941
pmcid: 3940190
Doeing DC, Solway J. Airway smooth muscle in the pathophysiology and treatment of asthma. J Appl Physiol. 2013;114:834–43.
doi: 10.1152/japplphysiol.00950.2012
pubmed: 23305987
pmcid: 3633438
Gunst S, Stropp JQ, Service J. Mechanical modulation of pressure-volume characteristics of contracted canine airways in vitro. J Appl Physiol. 1990;68:2223–9.
doi: 10.1152/jappl.1990.68.5.2223
pubmed: 2361927
Pratusevich VR, Seow CY, Ford LE. Plasticity in canine airway smooth muscle. J Gen Physiol. 1995;105:73–94.
doi: 10.1085/jgp.105.1.73
pubmed: 7730790
Luo L, Wang L, Paré PD, Seow CY, Chitano P. The Huxley crossbridge model as the basic mechanism for airway smooth muscle contraction. Am J Physiol Lung Cell Mol Physiol. 2019;317:L235–46. https://doi.org/10.1152/ajplung.00051.2019 . Epub 2019 May 22. PMID: 31116578; PMCID: PMC6734385.
doi: 10.1152/ajplung.00051.2019
pubmed: 31116578
pmcid: 6734385
LaPrad AS, Lutchen KR. Respiratory impedance measurements for assessment of lung mechanics: focus on asthma. Respir Physiol Neurobiol. 2008;163:64–73. https://doi.org/10.1016/j.resp.2008.04.015 .
doi: 10.1016/j.resp.2008.04.015
pubmed: 18579455
pmcid: 2637462
Pellegrino R, Pompilio P, Quaranta M, Aliverti A, Kayser B, Miserocchi G, Fasano V, Cogo A, Milanese M, Cornara G, Brusasco V, Dellacà R. Airway responses to methacholine and exercise at high altitude in healthy lowlanders. J Appl Physiol. 2010;108:256–65.
doi: 10.1152/japplphysiol.00677.2009
pubmed: 19940099
Winkler T. Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma. J Eng Sci Med Diagn Ther. 2019;2:0110051–6. https://doi.org/10.1115/1.4042478 . Epub 2019 Feb 13. PMID: 32328574; PMCID: PMC7164500.
doi: 10.1115/1.4042478
pubmed: 32328574
Gobbi A, Pellegrino R, Gulotta C, Antonelli A, Pompilio P, Crimi C, Torchio R, Dutto L, Parola P, Dellacà RL, Brusasco V. Short-term variability in respiratory impedance and effect of deep breath in asthmatic and healthy subjects with airway smooth muscle activation and unloading. J Appl Physiol. 2013;115:708–15. https://doi.org/10.1152/japplphysiol.00013.2013 . Epub 2013 Jun 13 PMID: 23766502.
doi: 10.1152/japplphysiol.00013.2013
pubmed: 23766502
Pascoe CD, Seow CY, Paré PD, Bossé Y. Decrease of airway smooth muscle contractility induced by simulated breathing maneuvers is not simply proportional to strain. J Appl Physiol. 2013;114:335–43.
doi: 10.1152/japplphysiol.00870.2012
pubmed: 23195632
Rodarte JR, Noredin G, Miller C, Brusasco V, Pellegrino R. Lung elastic recoil during breathing at increased lung volume. J Appl Physiol. 1999;87:1491–5. https://doi.org/10.1152/jappl.1999.87.4.1491 .
doi: 10.1152/jappl.1999.87.4.1491
pubmed: 10517783
Karamaoun C, Haut B, Van Muylem A. A new role of the exhaled nitric oxide as a functional marker of peripheral airway caliber changes; a theoretical study. J Appl Physiol. 2018;124:1025–33.
doi: 10.1152/japplphysiol.00530.2017
pubmed: 29357478
Pellegrino R, Violante B, Nava S, Rampulla C, Brusasco V, Rodarte JR. Expiratory airflow limitation and hyperinflation during methacholine-induced bronchoconstriction. J Appl Physiol. 1993;75:1720–7. https://doi.org/10.1152/jappl.1993.75.4.1720 .
doi: 10.1152/jappl.1993.75.4.1720
pubmed: 8282625
Woolcock AJ, Read J. Lung volumes in exacerbations of asthma. Am J Med. 1966;41:259–73. https://doi.org/10.1016/0002-9343(66)90021-0 .
doi: 10.1016/0002-9343(66)90021-0
pubmed: 5912303
Lougheed MD, Lam M, Forkert L, Webb KA, O’Donnell DE. Breathlessness during acute bronchoconstriction in asthma. Pathophysiologic mechanisms Am Rev Respir Dis. 1993;148:1452–9. https://doi.org/10.1164/ajrccm/148.6_Pt_1.1452 .
doi: 10.1164/ajrccm/148.6_Pt_1.1452
pubmed: 8256884