Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H.

Thousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease.

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©2024 The Authors FASEB BioAdvances published by The Federation of American Societies for Experimental Biology.

Déclaration de conflit d'intérêts

All authors were employees of the GSK group of companies at the time of the study, with the exception of FB, who held a PhD studenship at the University of Florence, Italy. The authors DV and MJB are named inventors on patent applications related to fHbp polypeptides. MJB, DM report ownership of GSK shares.