A randomized controlled trial comparing tacrolimus versus hydrocortisone for the treatment of atopic dermatitis in children: new perspectives on interferon gamma-induced protein and growth-related oncogene-α.

Atopic dermatitis (AD) is a type of chronic inflammatory disorder that affects children. To investigate whether hydrocortisone or tacrolimus could be more effective for treating AD in children. This clinical randomized investigation included 100 children with AD who met the eligibility criteria. AD patients were recruited from Tanta University's Dermatology Department and divided into two groups ( Tacrolimus group showed a significant reduction in serum levels of all measured biomarkers ( In children with AD, tacrolimus reduces inflammatory biomarkers better than hydrocortisone, suggesting its potential as a more effective treatment option. https://clinicaltrials.gov, identifier NCT05607901.

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Copyright © 2024 Binsaleh, Bahaa, Elmasry, Elberri, Kotkata, El-Khateeb, Kamal, El-samongy, Hamouda, Alghamdi, Alrubia, Salahuddin and Eltantawy.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.