BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during
C. elegans
chromosomes
gene expression
genetics
genomics
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 Aug 2024
08 Aug 2024
Historique:
received:
31
05
2022
accepted:
07
08
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
8
8
2024
Statut:
aheadofprint
Résumé
The preservation of genome integrity during sperm and egg development is vital for reproductive success. During meiosis, the tumor suppressor BRCA1/BRC-1 and structural maintenance of chromosomes 5/6 (SMC-5/6) complex genetically interact to promote high fidelity DNA double strand break (DSB) repair, but the specific DSB repair outcomes these proteins regulate remain unknown. Using genetic and cytological methods to monitor resolution of DSBs with different repair partners in
Identifiants
pubmed: 39115289
doi: 10.7554/eLife.80687
pii: 80687
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35GM128890
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R00HD076165
Organisme : NIGMS NIH HHS
ID : T32GM007413
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R25HD070817
Organisme : NIGMS NIH HHS
ID : T32GM007464
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35GM128804
Pays : United States
Informations de copyright
© 2024, Toraason et al.
Déclaration de conflit d'intérêts
ET, AS, DA, JB, CR, NK, OR, DL The authors declare that no competing interests exist.