Spatial Ambiguity Correction in Coherence-based Average Sound Speed Estimation.

Sound speed estimation can potentially correct the focusing errors in medical ultrasound. Maximizing the echo spatial coherence as a function of beamforming sound speed is a known technique to estimate the average sound speed. However, beamformation with changing sound speed causes a spatial shift of the echo signals resulting in noise and registration errors in the average sound speed estimates. We show that the spatial shift can be predicted and corrected, leading to superior sound speed estimates. Methods are presented for axial and two-dimensional location correction. Methods were evaluated using simulations and experimental phantom data. The location correction strategies improved the variance of sound speed estimates and reduced artifacts in the presence of strong backscatter variations. Limitations of the proposed methods and potential improvement strategies were evaluated.