Lower Neutrophil Count Without Clinical Consequence Among Children of African Ancestry Living With HIV in Canada.
Journal
Journal of acquired immune deficiency syndromes (1999)
ISSN: 1944-7884
Titre abrégé: J Acquir Immune Defic Syndr
Pays: United States
ID NLM: 100892005
Informations de publication
Date de publication:
01 Sep 2024
01 Sep 2024
Historique:
received:
07
12
2023
accepted:
13
05
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
8
8
2024
Statut:
ppublish
Résumé
To investigate the association between African ancestry and neutrophil counts among children living with HIV (CLWH). We also examined whether medications, clinical conditions, hospitalization, or HIV virologic control were associated with low neutrophil counts or African ancestry. We conducted a secondary analysis of the Early Pediatric Initiation Canada Child Cure Cohort (EPIC4) Study, a multicenter prospective cohort study of CLWH across 8 Canadian pediatric HIV care centers. We classified CLWH according to African ancestry, defined as "African," "Caribbean," or "Black" maternal race. Longitudinal laboratory data (white blood cells, neutrophils, lymphocytes, viral load, and CD4 count) and clinical data (hospitalizations, AIDS-defining conditions, and treatments) were abstracted from medical records. Among 217 CLWH (median age 14, 55% female), 145 were of African ancestry and 72 were of non-African ancestry. African ancestry was associated with lower neutrophil counts, white blood cell counts, and neutrophil-lymphocyte ratios. Neutrophil count <1.5 × 109/L was detected in 60% of CLWH of African ancestry, compared with 31% of CLWH of non-African ancestry (P < 0.0001), representing a 2.0-fold higher relative frequency (95% CI: 1.4-2.9). Neutrophil count was on average 0.74 × 109/L (95% CI: 0.45 to 1.0) lower in CLWH of African ancestry (P < 0.0001). Neither neutrophil count<1.5 × 109/L nor African ancestry was associated with medications, hospitalizations, AIDS-defining conditions, or markers of virologic control (viral load, sustained viral suppression, and lifetime nadir CD4). In CLWH, African ancestry is associated with lower neutrophil counts, without clinical consequences. A flexible evaluation of neutrophil counts in CLWH of African ancestry may avoid unnecessary interventions.
Identifiants
pubmed: 39116334
doi: 10.1097/QAI.0000000000003467
pii: 00126334-202409010-00011
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-86Subventions
Organisme : International AIDS Society
ID : NA
Organisme : Canadian Foundation for AIDS Research (CANFAR)
ID : NA
Organisme : Women and Children's Health Research Institute (University of Alberta)
ID : NA
Organisme : Li Ka Shing Institute of Virology Undergraduate Summer Research Studentship (University of Alberta)
ID : NA
Investigateurs
Ariane Alimenti
(A)
Petronela Ancuta
(P)
Ari Bitnun
(A)
Jason Brophy
(J)
Jared Bullard
(J)
Tae-Wook Chun
(TW)
Hélène C F Côté
(HCF)
Joanne Embree
(J)
Michael T Hawkes
(MT)
Fatima Kakkar
(F)
Christos Karatzios
(C)
Rupert Kaul
(R)
John Kim
(J)
Valérie Lamarre
(V)
Pascal Lavoie
(P)
Terry Lee
(T)
Deborah M Money
(DM)
Dorothy Moore
(D)
Stanley Read
(S)
Robert Reinhard
(R)
Lindy Samson
(L)
Paul Sandstorm
(P)
Laura Sauve
(L)
Sandra Seigel
(S)
Joel Singer
(J)
Hugo Soudeyns
(H)
Ben Tan
(B)
Wendy Vaudry
(W)
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no funding or conflicts of interest to disclose.
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