Targeting the PINK1/Parkin Pathway: a new perspective in the prevention and therapy of diabetic retinopathy.

Diabetic Retinopathy Mitophagy PINK1 Parkin

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
06 Aug 2024
Historique:
received: 15 02 2024
revised: 17 05 2024
accepted: 05 08 2024
medline: 9 8 2024
pubmed: 9 8 2024
entrez: 8 8 2024
Statut: aheadofprint

Résumé

Diabetic retinopathy (DR) is a microvascular complication of diabetes characterized by neurovascular impairment of the retina. The dysregulation of the mitophagy process occurs before apoptotic cell death and the appearance of vascular damage. In particular, mitochondrial alterations happen during DR development, supporting the hypothesis that mitophagy is negatively correlated to disease progression. This process is mainly regulated by the PTEN-induced putative kinase protein 1 (PINK1) /Parkin pathway whose activation promotes mitophagy. In this review, we will summarize the evidence reported in the literature demonstrating the involvement of the PINK1/Parkin pathway in diabetic retinopathy-induced retinal degeneration.

Identifiants

DOI: 10.1016/j.exer.2024.110024 PMID: 39117133
pubmed: 39117133
pii: S0014-4835(24)00245-8
doi: 10.1016/j.exer.2024.110024
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

110024

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Agata Grazia D'Amico (AG)

Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.

Grazia Maugeri (G)

Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Sciences, University of Catania, 95100 Catania, Italy.

Benedetta Magrì (B)

Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Sciences, University of Catania, 95100 Catania, Italy.

Claudio Bucolo (C)

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, 95100 Catania, Italy.

Velia D'Agata (V)

Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Sciences, University of Catania, 95100 Catania, Italy. Electronic address: vdagata@unict.it.

Classifications MeSH