Unraveling the magnesium connection: the Cincinnati PPG's pioneering work on mineral metabolism in diabetes in pregnancy.

to review the contribution of the Cincinnati Program Project grant (PPG) to the understanding and treatment of neonatal hypocalcemia (NHC) in infants of mothers with diabetes. retrospective review of the PPG publications related to mineral metabolism in type 1 diabetic pregnant women Results: the PPG investigators first described the epidemiology and the additional risk factors for NHC, namely prematurity and neonatal asphyxia, but they also recognized the independent effect of maternal diabetes mellitus. They explored the link between NHC and maternal/neonatal hypomagnesemia, and finally conducted a - randomized controlled trial that demonstrated the ability to prevent NHC by administration of magnesium sulfate soon after birth. The PPG in its various phases revealed the important role that Magnesium plays in the regulation of mineral metabolism in pregnancy and, in particular, in pregnancies complicated by pre-gestational diabetes.  .

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The authors declare that they have no conflict of interest.