Advances in the mechanism of small nucleolar RNA and its role in DNA damage response.
Cell cycle checkpoints
Cell death
DNA damage repair
DNA damage response (DDR)
Oxidative stress
Small nucleolar RNAs (snoRNAs)
Journal
Military Medical Research
ISSN: 2054-9369
Titre abrégé: Mil Med Res
Pays: England
ID NLM: 101643181
Informations de publication
Date de publication:
08 Aug 2024
08 Aug 2024
Historique:
received:
24
10
2023
accepted:
08
07
2024
medline:
9
8
2024
pubmed:
9
8
2024
entrez:
8
8
2024
Statut:
epublish
Résumé
Small nucleolar RNAs (snoRNAs) were previously regarded as a class of functionally conserved housekeeping genes, primarily involved in the regulation of ribosome biogenesis by ribosomal RNA (rRNA) modification. However, some of them are involved in several biological processes via complex molecular mechanisms. DNA damage response (DDR) is a conserved mechanism for maintaining genomic stability to prevent the occurrence of various human diseases. It has recently been revealed that snoRNAs are involved in DDR at multiple levels, indicating their relevant theoretical and clinical significance in this field. The present review systematically addresses four main points, including the biosynthesis and classification of snoRNAs, the mechanisms through which snoRNAs regulate target molecules, snoRNAs in the process of DDR, and the significance of snoRNA in disease diagnosis and treatment. It focuses on the potential functions of snoRNAs in DDR to help in the discovery of the roles of snoRNAs in maintaining genome stability and pathological processes.
Identifiants
pubmed: 39118131
doi: 10.1186/s40779-024-00553-4
pii: 10.1186/s40779-024-00553-4
doi:
Substances chimiques
RNA, Small Nucleolar
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
53Subventions
Organisme : National Natural Science Foundation of China
ID : 32071240
Organisme : National Natural Science Foundation of China
ID : 82373526
Informations de copyright
© 2024. The Author(s).
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