Exercise and nutrition to improve cancer Treatment-Related outcomes (ENICTO).

Journal

Journal of the National Cancer Institute
ISSN: 1460-2105
Titre abrégé: J Natl Cancer Inst
Pays: United States
ID NLM: 7503089

Informations de publication

Date de publication:
08 Aug 2024
Historique:
received: 29 03 2024
revised: 26 06 2024
accepted: 16 07 2024
medline: 9 8 2024
pubmed: 9 8 2024
entrez: 9 8 2024
Statut: aheadofprint

Résumé

Chemotherapy treatment-related side-effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity (RDI). The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium, to address this knowledge gap. This paper describes the mechanisms hypothesized to underpin intervention effects on clinically-relevant treatment outcomes, briefly outlines each project's distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the paper includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that cancer patients could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve RDI for a curative outcome.

Identifiants

DOI: 10.1093/jnci/djae177 PMID: 39118255
pubmed: 39118255
pii: 7730230
doi: 10.1093/jnci/djae177
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press.

Auteurs

Kathryn H Schmitz (KH)

Hematology and Oncology, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, PA, USA.

Justin C Brown (JC)

Department of Cancer Energetics, Pennington Biomedical Research Center, Baton Rouge, LA, USA.

Melinda L Irwin (ML)

Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.

Kim Robien (K)

Department of Exercise and Nutrition Sciences and Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.

Jessica M Scott (JM)

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.

Nathan A Berger (NA)

Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University, and Case Comprehensive Cancer Center, Cleveland, OH, USA.

Bette Caan (B)

Division of Research, Kaiser Permanente of Northern California, Oakland, CA, USA.

Andrea Cercek (A)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tracy E Crane (TE)

Department of Medicine, Division of Medical Oncology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA.

Scott R Evans (SR)

Biostatistics Center and Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA.

Jennifer A Ligibel (JA)

Division of Breast Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Jeffrey A Meyerhardt (JA)

Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, MA, USA.

Tanya Agurs-Collins (T)

Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.

Karen Basen-Engquist (K)

Department of Health Disparities Research, MD Anderson Cancer Center, Houston, TX, USA.

Jennifer W Bea (JW)

Health Promotion Sciences, University of Arizona, and University of Arizona Cancer Center, Tucson, AZ, USA.

Sheng F Cai (SF)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Brenda Cartmel (B)

Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.

Vernon M Chinchilli (VM)

Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

Wendy Demark-Wahnefried (W)

Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.

Christina M Dieli-Conwright (CM)

Division of Population Sciences, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

Loretta DiPietro (L)

Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.

Shawna E Doerksen (SE)

Hematology and Oncology, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, PA, USA.

Sharon L Edelstein (SL)

Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA.

Joanne Elena (J)

Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.

William Evans (W)

Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.

Leah M Ferrucci (LM)

Department of Chronic Disease Epidemiology, Yale School of Public Health, and Yale Cancer Center, New Haven, CT, USA.

Julia Foldi (J)

Hematology and Oncology, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, PA, USA.

Sarah Freylersythe (S)

Department of Medicine, Division of Medical Oncology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA.

Helena Furberg (H)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lee W Jones (LW)

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.

Ross Levine (R)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Chaya S Moskowitz (CS)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cynthia Owusu (C)

Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, USA.

Frank Penedo (F)

Departments of Psychology and Medicine, and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.

Borsika A Rabin (BA)

Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.

Elena Ratner (E)

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT, USA.

Margaret Rosenzweig (M)

School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.

Talya Salz (T)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tara Sanft (T)

Section of Medical Oncology, Yale University, New Haven, CT, USA.

Matthew Schlumbrecht (M)

Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, Miami, FL, USA.

Guillaume Spielmann (G)

School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.

Cynthia A Thomson (CA)

Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.

Ashley H Tjaden (AH)

Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA.

Martin R Weiser (MR)

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Shengping Yang (S)

Department of Biostatistics, Pennington Biomedical Research Center, Baton Rouge, LA, USA.

Anthony F Yu (AF)

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.

Frank M Perna (FM)

Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.

Classifications MeSH