A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol.

Journal

Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951

Informations de publication

Date de publication:
07 Aug 2024
Historique:
received: 14 05 2024
accepted: 27 06 2024
medline: 9 8 2024
pubmed: 9 8 2024
entrez: 9 8 2024
Statut: epublish

Résumé

Azobenzene analogues of the tubulin polymerisation inhibitor combretastatin A4 (PSTs) were previously developed to optically control microtubule dynamics in living systems, with subsecond response time and single-cell spatial precision, by reversible

Identifiants

DOI: 10.1039/d4sc03072a PMID: 39118608 PMC: PMC11304547
pubmed: 39118608
doi: 10.1039/d4sc03072a
pii: d4sc03072a
pmc: PMC11304547
doi:

Types de publication

Journal Article

Langues

eng

Pagination

12301-12309

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

K. S., A. J., and P. P. are employees of PHIO Scientific GmbH. There are no conflicts of interest.

Auteurs

Martin Reynders (M)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Małgorzata Garścia (M)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Adrian Müller-Deku (A)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Maximilian Wranik (M)

Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut Villigen 5232 Switzerland.

Kristina Krauskopf (K)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Luis de la Osa de la Rosa (L)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Konstantin Schaffer (K)

Faculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.
PHIO Scientific GmbH Munich 81371 Germany.

Anna Jötten (A)

Faculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.
PHIO Scientific GmbH Munich 81371 Germany.

Alexander Rode (A)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Valentin Stierle (V)

Faculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.

Yvonne Kraus (Y)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Benedikt Baumgartner (B)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Ahmed Ali (A)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Andrei Bubeneck (A)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Trina Seal (T)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.

Michel O Steinmetz (MO)

Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut Villigen 5232 Switzerland.
Biozentrum, University of Basel Basel 4056 Switzerland.

Philipp Paulitschke (P)

Faculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.
PHIO Scientific GmbH Munich 81371 Germany.

Oliver Thorn-Seshold (O)

Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
ORCID: 0000-0003-3981-651X

Classifications MeSH