Hematological malignancy-associated pyoderma gangrenosum: evaluating the magnitude of the association.
acute leukemia
case-control study
cohort study
hematologic malignancies
multiple myeloma
non-Hodgkin lymphoma
pyoderma Gangrenosum
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2024
2024
Historique:
received:
29
04
2024
accepted:
17
07
2024
medline:
9
8
2024
pubmed:
9
8
2024
entrez:
9
8
2024
Statut:
epublish
Résumé
Hematologic malignancies (HMs) are well-known underlying comorbidities of pyoderma gangrenosum (PG). However, studies quantifying the likelihood of PG after HMs are yet to be performed. To investigate the bidirectional association between PG and several HMs, namely acute leukemia, chronic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma. A population-based retrospective cohort study was conducted to study the risk of HMs in patients with PG ( The prevalence of preexisting HM was higher in patients with PG than in controls (6.7% vs. 0.9%, respectively). The likelihood of having PG was significantly greater among patients with a history of HM (adjusted OR, 7.88; 95% CI, 3.85-16.15; HM, particularly acute leukemia and multiple myeloma, are associated with an elevated likelihood of provoking PG.
Sections du résumé
Background
UNASSIGNED
Hematologic malignancies (HMs) are well-known underlying comorbidities of pyoderma gangrenosum (PG). However, studies quantifying the likelihood of PG after HMs are yet to be performed.
Objective
UNASSIGNED
To investigate the bidirectional association between PG and several HMs, namely acute leukemia, chronic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma.
Methods
UNASSIGNED
A population-based retrospective cohort study was conducted to study the risk of HMs in patients with PG (
Results
UNASSIGNED
The prevalence of preexisting HM was higher in patients with PG than in controls (6.7% vs. 0.9%, respectively). The likelihood of having PG was significantly greater among patients with a history of HM (adjusted OR, 7.88; 95% CI, 3.85-16.15;
Conclusion
UNASSIGNED
HM, particularly acute leukemia and multiple myeloma, are associated with an elevated likelihood of provoking PG.
Identifiants
pubmed: 39118665
doi: 10.3389/fmed.2024.1425454
pmc: PMC11306151
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1425454Informations de copyright
Copyright © 2024 Kridin, Ankary-Khaner, Kridin, Cohen and Badarny.
Déclaration de conflit d'intérêts
AC served as an advisor, investigator, or speaker for Abbvie, BI, Dexcel Pharma, Janssen, Novartis, Perrigo, Pfizer, and Rafa. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.