A Volume-Adjustable Artificial Womb for Extremely Preterm Infants.

adjustable silicone sac artificial amniotic sac artificial womb extremely preterm infant perinatal life support

Journal

Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516

Informations de publication

Date de publication:
2024
Historique:
received: 04 03 2024
accepted: 24 06 2024
medline: 9 8 2024
pubmed: 9 8 2024
entrez: 9 8 2024
Statut: epublish

Résumé

More than 13 million children are born preterm annually. Prematurity-related mortality accounts for 0.9 million deaths worldwide. The majority of those affected are Extremely Preterm Infants (gestational age less than 28 weeks). Immaturity causes organ failure and specific morbidities like germinal matrix hemorrhage, bronchopulmonary dysplasia, and necrotizing enterocolitis. Artificial womb and placenta technologies address these issues. As a bridge-to-life technology, they provide a liquid environment to allow organ maturation under more physiological conditions. The proposed artificial womb can adapt to fetal growth. Volume adjustment is achieved by removing fluid from the interspace between an inner and outer chamber. Results of the

Identifiants

pubmed: 39119064
doi: 10.3389/ti.2024.12947
pii: 12947
pmc: PMC11306982
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

12947

Informations de copyright

Copyright © 2024 Heyer, Schubert, Seitz, Steinle, Arens, Orlikowsky, Steinseifer, Schmitz-Rode, Jansen and Schoberer.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Jan Heyer (J)

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Aachen, Germany.

Franziska Schubert (F)

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Aachen, Germany.

Alexander L Seitz (AL)

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Aachen, Germany.

Yannick Steinle (Y)

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Aachen, Germany.

Jutta Arens (J)

Engineering Organ Support Technologies Group, Department of Biomechanical Engineering, University of Twente, Enschede, Netherlands.

Thorsten Orlikowsky (T)

Pediatric Clinic, Neonatology Section, RWTH Aachen University and University Hospital, Aachen, Germany.

Ulrich Steinseifer (U)

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Aachen, Germany.

Thomas Schmitz-Rode (T)

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Aachen, Germany.

Sebastian V Jansen (SV)

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Aachen, Germany.

Mark Schoberer (M)

Pediatric Clinic, Neonatology Section, RWTH Aachen University and University Hospital, Aachen, Germany.

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Classifications MeSH