Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms.
magnetic catheter
magnetic control
magnetic nanoparticle swarm
magnetic nanoparticles
targeted delivery
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
09 Aug 2024
09 Aug 2024
Historique:
revised:
26
07
2024
received:
17
04
2024
medline:
9
8
2024
pubmed:
9
8
2024
entrez:
9
8
2024
Statut:
aheadofprint
Résumé
The initial delivery of small-scale magnetic devices such as microrobots is a key, but often overlooked, aspect for their use in clinical applications. The deployment of these devices within the dynamic environment of the human body presents significant challenges due to their dispersion caused by circulatory flows. Here, a method is introduced to effectively deliver a swarm of magnetic nanoparticles in fluidic flows. This approach integrates a magnetically navigated robotic microcatheter equipped with a reservoir for storing the magnetic nanoparticles. The microfluidic flow within the reservoir facilitates the injection of magnetic nanoparticles into the fluid stream, and a magnetic field gradient guides the swarm through the oscillatory flow to a target site. The microcatheter and reservoir are engineered to enable magnetic steering and injection of the magnetic nanoparticles. To demonstrate this approach, experiments are conducted utilizing a spinal cord phantom simulating intrathecal catheter delivery for applications in the central nervous system. These results demonstrate that the proposed microcatheter successfully concentrates nanoparticles near the desired location through the precise manipulation of magnetic field gradients, offering a promising solution for the controlled deployment of untethered magnetic micro-/nanodevices within the complex physiological circulatory systems of the human body.
Identifiants
pubmed: 39119930
doi: 10.1002/advs.202404061
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2404061Subventions
Organisme : European Research Council
ID : 771565
Pays : International
Organisme : Portugal through FCT/MCTES (PIDDAC)
ID : LA/P/0045/2020
Organisme : Portugal through FCT/MCTES (PIDDAC)
ID : UIDB/00532/2020
Organisme : Portugal through FCT/MCTES (PIDDAC)
ID : UIDP/00532/2020
Organisme : Eidgenössische Technische Hochschule Zürich
ID : 22-2 ETH-040
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 198643
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 197017
Organisme : H2020 Future and Emerging Technologies
ID : 952152
Organisme : H2020 European Research Council
ID : 801464
Informations de copyright
© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
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