Developing Topics.
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
9
8
2024
pubmed:
9
8
2024
entrez:
9
8
2024
Statut:
ppublish
Résumé
The novel diffusion-based Neurite Orientation and Dispersion Imaging (NODDI) model may provide complementary information to Diffusion Tensor Imaging (DTI) to increase sensitivity in characterizing tissue microarchitecture. We examined if one or a combination of both approaches can improve our understanding of at-risk tissue in and around white matter hyperintensities (WMH). From ADNI3, we identified individuals [n = 54, age = 78 ± 7, 46% F) with concurrent measures of multi-shell DTI, 3D FLAIR, and 3D MPRAGE. We segmented WMH from structural data using Lesion Segmentation Toolbox. We derived DTI (FA, MD) and NODDI parameters (NDI, ODI, F Normalized DTI and NODDI parameters representing spatial variations within the 5 mm region are shown in Fig 1A. Table 1 shows p-values comparing DTI and NODDI parameters between WMH the subsequent regions outside it. Compared to WMH, F In the WMHs and its immediate vicinity, low FA, NDI, ODI suggest lower cell density, while low F
Sections du résumé
BACKGROUND
BACKGROUND
The novel diffusion-based Neurite Orientation and Dispersion Imaging (NODDI) model may provide complementary information to Diffusion Tensor Imaging (DTI) to increase sensitivity in characterizing tissue microarchitecture. We examined if one or a combination of both approaches can improve our understanding of at-risk tissue in and around white matter hyperintensities (WMH).
METHOD
METHODS
From ADNI3, we identified individuals [n = 54, age = 78 ± 7, 46% F) with concurrent measures of multi-shell DTI, 3D FLAIR, and 3D MPRAGE. We segmented WMH from structural data using Lesion Segmentation Toolbox. We derived DTI (FA, MD) and NODDI parameters (NDI, ODI, F
RESULT
RESULTS
Normalized DTI and NODDI parameters representing spatial variations within the 5 mm region are shown in Fig 1A. Table 1 shows p-values comparing DTI and NODDI parameters between WMH the subsequent regions outside it. Compared to WMH, F
CONCLUSION
CONCLUSIONS
In the WMHs and its immediate vicinity, low FA, NDI, ODI suggest lower cell density, while low F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e082408Informations de copyright
© 2023 the Alzheimer's Association.